new antifibrotic cGAS/STING signaling pathway that suppresses pathological angiogenesis in liver and kidney We showed that cGAS expression was induced in fibrotic liver and kidney, but suppressed in endothelial cells. cGAS genetic deletion promoted liver and kidney fibrosis and pathological angiogenesis, including GPCR)-based antagonist that blocks the profibrotic activity of endothelial YAP, attenuated liver and kidney Further, pharmacological targeting of cGAS/STING-YAP axis exhibits the potential to alleviate liver and kidney

Here, we show that human GPR125 likely undergoes cis-autoproteolysis when expressed in canine kidney epithelial MDCK cells and human embryonic kidney HEK293 cells.

development, PGE2 signaling regulates embryogenesis, hepatocyte differentiation, hematopoiesis, and kidney

News < GPCRs in Oncology and Immunology Noval insights and therapeutic strategies for tumor-induced kidney

Pluznick discovered that olfactory receptors in mice are also expressed in their kidneys and blood vessels This work contributes to a better understanding of how the kidney helps maintain homeostasis in humans

Such pro-inflammatory immune cells may travel to tissues such as the brain, the lung, the kidney etc