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683 items found for " Molecular targeting"

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  • Molecular targets of psychedelic-induced plasticity

    August 2022 "Psychedelic research across different disciplines and biological levels is growing at a remarkably fast pace. In the prospect of a psychedelic drug becoming again an approved treatment, much of these efforts have been oriented toward exploring the relationship between the actual psychedelic effects and those manifestations of therapeutic interest. Considering the central role of the serotonin 5-HT2A receptor in the distinct effects of psychedelics in human psyche, neuropharmacology sits at the center of this debate and exploratory continuum. Here we discuss some of the most recent findings in human studies and contextualize them considering previous preclinical models studying phenomena related to synaptic plasticity. A special emphasis is placed on knowledge gaps, challenges, and limitations to evaluate the underpinnings of psychedelics' potential antidepressant action." Read more at the source #DrGPCR #GPCR #IndustryNews

  • Rhodopsin as a Molecular Target to Mitigate Retinitis Pigmentosa

    Targeting rhodopsin with small molecule chaperones to improve the folding and stability of the mutant This review provides an update on the current knowledge regarding small molecule compounds that have

  • Molecular insights into psychedelic drug action

    such applications, however, is a clearer understanding of how these drugs exert their effects at the molecular Here we review the current knowledge regarding the molecular details of psychedelic drug actions and

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  • Interplay between G protein-coupled receptors and nanotechnology

    Although GPCRs are the molecular targets of the majority of marketed drugs, the poor pharmacokinetics of GPCRs on the surface of various types of cells, GPCR ligands can endow nanoparticles with active targeting It will provide a fundamental platform for developing powerful and safe GPCR-targeted drugs and nanoparticle STATEMENT OF SIGNIFICANCE: GPCRs as molecular targets for the majority of marketed drugs are naturally targeting , Nanoparticles , Signal transduction Source Contribute to the GPCR News Coming soon Become

  • Ep 71 with Dr. Jean Martin Beaulieu

    Beaulieu’s research is aimed at understanding how cellular and molecular mechanisms regulated by psychoactive These receptors belong to the super-family of G-protein coupled receptors (GPCR), the major molecular target for drug development. In particular, D2R is the main pharmacological target of antipsychotic drugs prescribed for schizophrenia Beaulieu Lab has demonstrated that mood stabilizer drugs (e.g. lithium) used for bipolar disorder therapy target

  • Interrogating Multiscale Receptors Functions in Space

    Beaulieu’s research is aimed at understanding how cellular and molecular mechanisms regulated by psychoactive These receptors belong to the super-family of G-protein coupled receptors (GPCR), the major molecular target for drug development. In particular, D2R is the main pharmacological target of antipsychotic drugs prescribed for schizophrenia Beaulieu Lab has demonstrated that mood stabilizer drugs (e.g. lithium) used for bipolar disorder therapy target

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