VAMP2 can interact with other GPCRs, such as the beta-2 adrenergic receptor and the mu-opioid receptor (MOR this technology, they evidenced the presence of VAMP2, specifically in recycling vesicles containing MOR These data are fascinating because in the case of MOR, which is a receptor with several splicing variants modulated by different opioids, either endogenous or exogenous, promoving a differential organization of MOR Since MOR receptor regulates pain perception and reward, the dysfunction in the MOR-SNARE complex interaction

EOPs): β-endorphin, enkephalins and dynorphins, and four opioid receptors (ORs): μ-opioid receptor (MOR several reports that have addressed the differences in the mechanisms of transduction triggered by MOR Therefore to understand better the functions of arrestins in MOR signaling, Shiraki et al., explored the function of β-arrestin 2 in MOR signaling using the SH-SY5Y cell line that endogenously expresses MOR and was modified through CRISPR/Cas9 to knock out β-arrestin 1 and 2 gene expression.

June 2022 "Ottawa, Canada, May 10, 2022 — Orion Biotechnology Canada Ltd, a drug discovery and development Oliver Hartley , Orion’s Vice-President Drug Discovery, will present Orion’s novel technology for targeting His presentations will describe Orion’s drug discovery platform, one of the fastest drug discovery solutions Hartley will also present new data on Orion’s CCR2 antagonist, OB-004, demonstrating the ability of this

for the Nanoengineering Materials Research Center and developing thermodynamic processing methods for Iron-based

using a novel highly specific small molecule inhibitor of GPR68 named Ogremorphin (OGM) to induce the iron

After a fellowship of the German Research Council (DFG) at the Mayo Clinic, Rochester, MN, he obtained