Heterotrimeric G proteins couple activated G protein-coupled receptors (GPCR) to intracellular signaling pathways

the role of G-protein-coupled receptors (GPCR) in cancer is acknowledged, their underlying signaling pathways PAR4 emerges as a potent oncogene, capable of inducing tumor generation.

cells and decreases their response to paclitaxel by forming a vicious cycle with IGF1/IGF1R signaling pathway competitively binding to IGF1R with ubiquitin E3 ligase MDM2, thereby activating its downstream signaling pathways such as NF-κB, PI3K/AKT, and MAPK/ERK pathways given their critical roles in breast tumorigenesis and IGF1, in turn, stimulated GASP1 expression by activating the PI3K/AKT pathway, forming a vicious cycle

therapy resistance in high-grade serous ovarian carcinoma cells, whereas silencing UCA1 reverses these oncogenic UCA1 sequesters let-7 miRNAs, effectively neutralizing their tumor-suppressive functions involving key oncogenes Yong Sang Song , Danny N Dhanasekaran Tags GPCR , High Grade Serous Ovarian Carcinoma , Let-7 miRNAs , Oncogenic Pathways , Ovarian Cancer , Therapy Resistance , UCA1 , lncRNA Source Contribute to the GPCR News Coming

by enhancing signaling mediated by sphingosine-1-phosphate (S1P), a bioactive lipid that stimulates oncogenic pathways in glioblastoma.

< GPCR News < GPCRs in Oncology and Immunology Systems modeling of oncogenic G-protein and GPCR signaling reveals unexpected differences in downstream pathway activation Published date July 16, 2024 Abstract CysLT2R was impaired at activating the FAK/YAP/TAZ pathway relative to Gαq/11. our bioinformatic analysis uncovers a role for co-occurring mutations involving the plexin/semaphorin pathway , which has been shown capable of activating this pathway.