October 2022 "The cAMP-dependent protein kinase (PKA) system represents a primary cell-signaling pathway PKA facilitates the actions of hormones, neurotransmitters and other signaling molecules that bind G-protein Through its control of synaptic events, exocytosis, transcriptional regulation, and more, PKA signaling Neural PKA signaling is regulated by afferent and peripheral efferent signals that link specific neural While limited, human studies infer differential regulation of the PKA system in obese compared to lean

Learn about communication between GPCRs and PKA, Class F GPCR Smoothened & the Hedgehog signaling pathway

regulation of mTORC1 by upstream stimuli, with a specific focus on G-protein coupled receptor (GPCR) signaling Therefore, understanding the molecular underpinnings of these pathways will undoubtedly be promising

signaling pathway Published date March 2, 2024 Abstract " Background: Novel therapeutic targets are Western blotting demonstrated different expressions of autophagy and the Hippo-PKA signal pathway. pathway. Transcriptomic sequencing suggested the involvement of the Hippo signaling pathway in the action of RGS20 signaling pathway , Proliferation , RGS20 Source Contribute to the GPCR News Coming soon Become a Contributor

< GPCR News < GPCRs in Oncology and Immunology The GPCR-Gαs-PKA signaling axis promotes T cell dysfunction transgenic mice expressing a chemogenetic CD8-restricted Gαs-DREADD to activate CD8-restricted Gαs signaling and show that a Gαs-PKA signaling axis promotes CD8+ T cell dysfunction and immunotherapy failure. in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

Committee Sponsors GPCR Retreat Program < Back to schedule Unveiling Non-Canonical Functions for Gαq Signaling Pathways Date & Time Friday, November 3rd / 11:55 AM About Catalina Ribas " Dr. During this period and her doctoral thesis, she has deepened the regulatory mechanisms of GPCR signaling complex (AGS, de “Activators of G-protein signaling). Ribas has characterized the existence of a new signaling pathway with a relevant role in cardiac hypertrophy