Here, we examine how HH controls SMO subcellular localization and activity in a polarized epithelium

adhesion GPCR that traffics with Dlg1 to the basolateral membrane and regulates epithelial apicobasal polarity GPR125 (ADGRA3), an orphan adhesion GPCR, has been shown to modulate planar cell polarity in gastrulating Furthermore, in polarized MDCK cells, GPR125 is exclusively recruited to the basolateral domain of the likely requires the C-terminal PDZ-domain-binding motif of GPR125 and its interaction with the cell polarity basolateral protein GPR125, an autocleavable adhesion GPCR, appears to play a crucial role in apicobasal polarization

macrophages through enhancing NLRP3 inflammasome activation, while the loss of GPR84 prevents the M1 polarization CLH536, a novel GPR84 antagonist discovered by us, suppresses colitis by reducing the polarization and

LUAD mice, we find that A2aR highly expressed on LUAD cells promotes the secretion of chemokines and polarizing Notably, the M2 polarization of TAMs can also be prevented by inhibiting A2aR in vitro. Together, our studies demonstrate that A2aR on LUAD cells drives TAMs migration and polarization, and Tags A2aR , Lung adenocarcinoma , Migration , Polarization , Targeted therapy , Tumor-associated macrophages

Senthil Muthuswamy at Cold Spring Harbor Laboratory and probed the roles of polarity proteins (Feigin They also discussed his research on cell polarity and its role in cancer progression, his work on G-protein Mike's Research on Cell Polarity and GPCRs in Cancer Mike shared his research on cell polarity and its role in cancer progression, particularly focusing on the potential of disrupted cell polarity as a driver

macrophage migration, and studies in vitro confirmed that whereas BLT2 does not mediate macrophage polarization