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740 items found for " Progesterone receptor"

Posts (443)

  • Canonical chemokine receptors as scavenging “decoys”

    all these situations, chemokines interact with seven-transmembrane chemokine-type G protein-coupled receptors (chemokine receptors, CKRs) and glycosaminoglycans (GAGs) to regulate the movement of leukocytes throughout In humans there are approximately 45 chemokines, 19 chemotactic or G-protein coupled chemokine receptors (CKRs) that signal via Gαi and 4 official atypical chemokine receptors (ACKRs) which engage in ligand CCR2 is an example of a dual-function receptor that directly regulates both cell migration and scavenging

  • Structural basis for receptor selectivity and inverse agonism in S1P5 receptors

    The bioactive lysophospholipid sphingosine-1-phosphate (S1P) acts via five different subtypes of S1P receptors Several S1PR therapeutic drugs have been developed to treat these diseases; however, they lack receptor In this article, we describe a 2.2 Å resolution room temperature crystal structure of the human S1P5 receptor demonstrates a unique ligand-binding mode, involving an allosteric sub-pocket, which clarifies the receptor

  • The Impact of CB1 Receptor on Nuclear Receptors in Skeletal Muscle Cells

    influence predominantly arises via engagement with the principal two G-protein-coupled cannabinoid receptors Earlier publications have indicated that expression of CB1 receptor mRNA and protein has been recognized The part played by CB1 receptor activation or inhibition with respect to these functions and relevant This can be deduced from the qRT-PCR assays; triggering CB1 receptors amplifies both NR4A1 and NR4A3 The impact of ACEA is inhibited by the selective CB1 receptor antagonist, rimonabant.

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Other Pages (297)

  • Molecular characterization of breast cancer cell pools with normal or reduced ability to respond to progesterone: a study based on RNA-seq

    RNA-seq Published date August 8, 2023 Abstract "Background: About one-third of patients with estrogen receptor alpha (ERα)-positive breast cancer have tumors which are progesterone receptor (PR) negative. New evidence has shown that progesterone (P4) has an anti-proliferative effect in ERα-positive breast seven significantly enriched biological processes affected by PR and associated with G protein-coupled receptor response , RNA-seq , CRISPR/Cas9 , estrogen receptor alpha , gene expression , Progesterone receptor

  • Plenary Lecture | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem

    Plenary Lecture Identification and Functional Characterization of Adhesion GPCRs As Steroid Hormone Receptors and Hearing and Balance Receptors Abstract Only Available for AGPCR24 Attendees About Jin-Peng Sun " Since starting my laboratory in 2011, I has focused on G protein coupled receptors, in particular, the We have identified the receptor subfamily to sense the steroid hormones. progesterone and 17-hydroxyprogesterone membrane receptor are GPR126.

  • Involvement of Protease-Activated Receptor2 Pleckstrin Homology Binding Domain in Ovarian Cancer: Expression in Fallopian Tubes and Drug Design

    < GPCR News < GPCRs in Oncology and Immunology Involvement of Protease-Activated Receptor2 Pleckstrin While the involvement of G-protein-coupled receptors (GPCRs) in cancer is growing, GPCR-based therapies Here, we demonstrate the overexpression of protease-activated receptor 2 (PAR2), a GPCR member in the Grisaru-Granovsky , Shunit Armon , Tatyana Rudina , Priyanga Appasamy , Rachel Bar-Shavit Tags G-protein coupled receptors GPCRs) , fallopian tubes (FTs) , ovarian cancer , pleckstrin homology (PH) domain , protease-activated receptors

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