August 2022 A NanoBRET-Based H 3 R Conformational Biosensor to Study Real-Time H 3 Receptor Pharmacology allowed the detection of both (partial) agonism and inverse agonism on living cells in a microplate reader Hence, the H3R conformational biosensor in membranes might be a ready-to-use, high-throughput alternative Read more at the source #DrGPCR #GPCR #IndustryNews

Read more at the source #DrGPCR #GPCR #IndustryNews

the protonation of key residues surrounding an extracellular facing cavity resulted in conformational rearrangements observed in humans, potentially leading to inconsistencies in how mutations influence protein function in real-world advancement will be the integration of DMS with emerging sequencing technologies that allow for longer reads

Authors Charles H Williams , Leif R Neitzel , Jessica Cornell , Samantha Rea , Ian Mills , Maya S Silver

September 25, 2024 The G Protein-Coupled Receptor GPR56 Is an Inhibitory Checkpoint for NK Cell Migration Read simple on-off switches: deep dive into GPCR-ligand interactions Read More April 16, 2024 From DNA day to GPCR genomics Read More May 14, 2024 Illuminating GPCR Research: FRET and BRET-Based Sensors Shed Light on Cellular Signaling Read More Read more articles from our Contributors Call for GPCR papers September 6, 2023 opnMe GPCR Route 66+ project Read More October 1, 2022 GPCRs: Signal Transduction Read

Understanding real-time kinetics to predict activity and in vivo target coverage. Are there any specific textbooks or readings students should be aware of?