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Removal of G proteins by using CRISPR KO of Gαi (Gαi KO) or KO of all Gα subtypes (Gα_all KO) (M. Recruitment of both β-arrestin1 and β-arrestin2 was significantly diminished iin Gαi KO and Gα_all KO microscopy readouts revealed that CCL2-dependent internalization was partially decreased in GRK2/3 KO In line, β-Arrestin KO cells showed a major reduction in CCL14 scavenging by CCR1, in contrast with a minor effect observed for CCR2. β-arrestin KO cells revealed the rapid reassociation of Gαi and Gβγ

Additionally, using the Gαq/11 inhibitor YM-254890, GPCR kinase 2 and 3 (GRK2 and GRK3) KO cells, and Our PKC KO cell lines expand the repertoire of KO HEK293A cell lines available to research GPCR pharmacology pharmacological tools to study PKC isozymes generally lack specificity and/or potency, we present the PKC KO

with the multilumen phenotype, mitotic spindles are incorrectly oriented during cystogenesis in GPR125-KO

Authors Hyo In Kim , Jinbong Park , David Gallo , Sidharth Shankar , Barbora Konecna , Yohan Han , Valerie Banner-Goodspeed , Krystal R Capers , Seong-Gyu Ko , Leo E Otterbein , Kiyoshi Itagaki , Carl J Hauser

Authors Junyi Liang , Mohamed Seghiri , Pradeep Kumar Singh , Hyeon Gyu Seo , Ji Yeong Lee , Yoonjung Jo , Yong Bhum Song , Chulo Park , Piotr Zalicki , Jae-Yeon Jeong , Won-Ki Huh , Niña G Caculitan ,

this, we investigated their role in crystalline nephropathy by increasing the oxalate intake of GPR4 KO and OGR1 KO mice.  After 10 days of high-oxalate intake and 4 days of recovery, renal crystal content While GPR4 deficiency did not show major alterations in disease progression, OGR1 KO mice had higher When lowering the severity of the kidney injury, OGR1 KO mice were more prone to develop crystalline In this setting, OGR1 KO mice displayed an increased activation of the immune system and a higher production