vasopressin 2 receptor "Abstract Background and purpose: Venomous animals express numerous Kunitz-type peptides The mambaquaretin-1 (MQ1) peptide identified from the Dendroaspis angusticeps venom is the most selective antagonist of the arginine-vasopressin V2 receptor (V2R) and the only unique Kunitz-type peptide active We aimed to exploit other mamba venoms to enlarge the V2R-Kunitz peptide family and gain insight into MQs were produced by solid-phase peptide synthesis and characterized in vitro by binding and functional

that removes the inhibitory GAIN domain on the extracellular side of receptor and releases a stalk peptide We further provide physiological evidence of GPR110 activation via stalk peptide.

September 2022 "The glucagon-like peptide-1 receptor (GLP-1R) plays a key role in metabolism and is an

< GPCR News < GPCRs in Oncology and Immunology Chemokine N-terminal-derived peptides differentially regulate Here, we investigate the signaling capacity of peptides corresponding to truncated N-termini. These 3 to 10-residue peptides displayed weak potency but, surprisingly, retained their signaling on In contrast, none of the peptides generated a signal on CCR5, but a CCL3-derived tetrapeptide was a positive

Danger-signaling molecular patterns such as the N-formylated peptides that are formed during bacterial and mitochondrial protein synthesis and recognized by formyl peptide receptors (FPRs) and free fatty Short peptides and short chain fatty acids activate FPR1 and FFA2R, respectively, while longer peptides

GBP1 expression through GPCR receptor Mthl10 Published date January 29, 2024 Abstract "Growth-blocking peptide A functional analogue of GBP, stress-responsive peptide (SRP), was also identified in the same species It is expected that the biological responses of two structurally similar peptides should be coordinated