pharmacology and binding assay analysis Module 4 - New dimensions of activity: Allosteric modulators and kinetics

2022 Luciferase-based GloSensor™ cAMP assay: Temperature optimization and application to cell-based kinetic this regard, luminescence-based biosensors have revolutionized our ability to monitor GPCR signaling kinetics

September 2022 Roles of Focal Adhesion Kinase PTK2 and Integrin αIIbβ3 Signaling in Collagen- and GPVI-Dependent Here, we focused on disclosing the integrin-dependent roles of focal adhesion kinase (protein tyrosine kinase 2, PTK2), the shear-dependent collagen receptor GPR56 (ADGRG1 gene), and calcium and integrin-binding

December 2021 Neurocrine Biosciences Announces Positive Phase 3 Data for KINECT-HD Study Evaluating Valbenazine PRNewswire/ -- Neurocrine Biosciences (Nasdaq: NBIX) today announced positive top-line data from its Phase 3 KINECT-HD

Seo , Ji Yeong Lee , Yoonjung Jo , Yong Bhum Song , Chulo Park , Piotr Zalicki , Jae-Yeon Jeong , Won-Ki

Immunology Ovarian cancer G protein-coupled receptor 1 (OGR1) deficiency exacerbates crystal deposition and kidney When lowering the severity of the kidney injury, OGR1 KO mice were more prone to develop crystalline OGR1 deficiency, however, increases crystal deposition leading to impaired kidney function. Thus, OGR1 may be important to limit kidney crystal deposition, which might subsequently be relevant for the pathophysiology of oxalate kidney stones or other crystallopathies."

< GPCR News < GPCRs in Oncology and Immunology Minireview: functional roles of tissue kallikrein, kinins suffering from lung cancer is to target surface receptors overexpressed on tumor cells, such as GPCR-family kinin Considering the multiple functions of kinin receptors and KLKs, this review highlights their roles, even Villarroel-Espindola , Carlos D Figueroa , Pamela Ehrenfeld Tags KLKs , Kallikrein-related peptidases , Kinin receptors , Kinins , Lung cancer , SARS-CoV-2 Source Contribute to the GPCR News Coming soon Become