August 2022 GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin Serotonin (or 5-hydroxytryptamine, 5-HT) is an important neurotransmitter that activates 12 different G The structural basis for G protein subtype selectivity by these GPCRs remains elusive. We find that the macro-switch by the TM5-TM6 length is shared by class A GPCR-G protein structures.

Methods: To address this question, we studied mice that express a Gs-coupled designer G protein-coupled

Biosensors for monitoring G protein-coupled receptors (GPCRs), the most drugged class of proteins in

Stephen Ferguson About Dr. Stephen Ferguson Dr. Stephen Ferguson is a Professor in the Department of Cellular and Molecular Medicine at the University Marc G. receptor kinases and beta-arrestin in regulating G protein-coupled receptor endocytosis, trafficking Stephen Ferguson on the web Carlton University Canada Research Chairs Twitter ResearchGate LinkedIn Dr

Stephen Ferguson’s laboratory in the Departments of Cellular & Molecular Medicine and Neuroscience at the University of Ottawa as a Postdoctoral Fellow to explore novel G protein-coupled receptor (GPCR)

Stephen Ferguson’s laboratory in the Departments of Cellular & Molecular Medicine and Neuroscience at the University of Ottawa as a Postdoctoral Fellow to explore novel G protein-coupled receptor (GPCR)