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August 2022 "Opioid receptors (ORs) represent one of the most significant groups of G-protein coupled receptor (GPCR) drug targets and also act as prototypical models for GPCR function. In a constant effort to develop drugs with less side effects, and tools to explore the ORs nature and function, various (poly)pharmacological ligand design approaches have been performed. That is, besides classical ligands, a great number of bivalent ligands (i. e. aiming on two distinct OR subtypes), univalent heteromer-selective ligands and bitopic and allosteric ligands have been synthesized for the ORs. The scope of our review is to present the most important of the aforementioned ligands, highlight their properties and exhibit the current state-of-the-art pallet of promising drug candidates or useful molecular tools for the ORs." Read more at the source #DrGPCR #GPCR #IndustryNews

neuron morphogenesis and shapes chemo- and mechanosensation-dependent behavior in C. elegans via a trans Caenorhabditis elegans can also function independently of their seven-transmembrane domain and C terminus (trans Here, we show that Latrophilin-1 acts in trans to mediate morphogenesis of sensory structures in the This trans function is physiologically relevant in copulation behavior.

GPCR Podcast << Back to podcast list Jacob Lee & Jin Choe About this episode In this special episode Jacob Lee and Jin Choe met in ninth grade in English class and have been friends since. Although both went to the same college, Jacob and Jin choose different career paths. shared his struggles of managing samples and an incredible amount of data and projects in the lab with Jin GPCR Ecosystem Jin Choe on LinkedIn Jin Choe on Dr.

chemotaxis. " Authors Xuehua Xu , Xi Wen , Smit Bhimani , Amer Moosa , Dustin Parsons , HyunGee Ha , Tian

Authors Chulo Park , Jin-Woo Lee , Kiheon Kim , Dong-Seung Seen , Jae-Yeon Jeong , Won-Ki Huh Source