September 2022 Dynamics of tumor-associated macrophages in a quantitative systems pharmacology model antibody atezolizumab and nab-paclitaxel has shown clinical activity in advanced TNBC with PD-L1-positive tumor-infiltrating As tumor-associated macrophages (TAMs) serve as major contributors to the immuno-suppressive tumor microenvironment We show that through proper calibration, the model captures the macrophage heterogeneity in the tumor

and inflammation, all of which are influenced by the cellular and molecular microenvironment of the tumor techniques, have been tested to reduce the malignancy and generate a harmful microenvironment for the tumor therapeutic benefits of the β-adrenergic receptor antagonist, propranolol, were described in benign tumors

January 2022 ChemoCentryx Announces EU Approval of TAVNEOS® (avacopan) for the Treatment of ANCA-Associated active granulomatosis polyangiitis (GPA) or microscopic polyangiitis (MPA), the two main forms of ANCA-associated

A2aR on lung adenocarcinoma cells: A novel target for cancer therapy via recruiting and regulating tumor-associated macrophages Published date May 28, 2023 Abstract "Adenosine 2a receptor (A2aR), a typical GPCR with Here, we identify that A2aR is specifically expressed on tumor cells from lung adenocarcinoma (LUAD) patients, closely related to their prognosis and positively correlated with tumor-associated macrophages Tags A2aR , Lung adenocarcinoma , Migration , Polarization , Targeted therapy , Tumor-associated macrophages

< GPCR News < GPCRs in Oncology and Immunology Noval insights and therapeutic strategies for tumor-induced antidiuretic hormones in Drosophila models has provided valuable insights into the mechanisms underlying tumor-induced The implications of these findings for transforming the therapeutic approaches to renal complications associated insights could contribute to the advancement of diagnostic and therapeutic strategies for treating tumor-related

GPCRs in Oncology and Immunology G protein-coupled receptor-mediated signaling of immunomodulation in tumor Published date July 31, 2024 Abstract "G protein-coupled receptors (GPCRs) are essential contributors to tumor Here, we discuss the current understanding of the roles of GPCRs and their signaling pathways in tumor This expanded understanding of the role of GPCRs may shed light on the mechanisms underlying tumor progression Qiu, Bin Yu, Mei Ma Tags GPCRs , cancer immune checkpoints , cancer immunotherapy , immune cells , tumor