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In vivo, suppression of postsynaptic cAMP signaling in CA1 neurons prevented formation of both Schaffer-collateral and entorhinal-CA1/temporoammonic-path synapses, suggesting a general principle.

functions, and therapeutic targets Constitutive activity of the dopamine receptor D5R, highly expressed in CA1

in Neuroscience Astrocytic PAR1 and mGluR2/3 control synaptic glutamate time course at hippocampal CA1

In this study, we elucidate the tripartite interaction between LPA-signaling, UCA1, and let-7 miRNAs Results show that the elevated expression of UCA1 enhances cell proliferation, invasive migration, and therapy resistance in high-grade serous ovarian carcinoma cells, whereas silencing UCA1 reverses these ovarian cancer xenografts, demonstrating the therapeutic potential of targeting LPAR-UCA1-let-7 axis Thus, our results identify LPAR-UCA1-let-7 axis as a novel avenue for targeted treatment strategies."