September 2022 Signaling pathways activated by sea bass gonadotropin-inhibitory hormone peptides in COS Herein, we further elucidated the intracellular signaling pathways mediating in sea bass GnIH actions were challenged with both GnIH peptides, and this stimulatory action was significantly reduced by two inhibitors of the PKC pathway. Our results provide additional evidence for the understanding of signaling pathways activated by GnIH

September 2022 "In the Wnt-β-catenin pathway, Wnt binding to Frizzled (Fzd) and LRP5 or LRP6 (LRP5/6) co-receptors inhibits the degradation of the transcriptional coactivator β-catenin by recruiting the membrane recruits the β-catenin destruction complex, enabling the phosphorylation of LRP5/6, a key step in inhibiting We found that the affinity of Fzd for Dvl was not affected by Wnt ligands, in contrast to other members Our findings suggest a positive feedback loop in which Wnt-stimulated local PI(4,5)P2 production enhances

Historically, drug discovery efforts targeting GPCRs focused on G-protein-dependent signaling pathways alongside the G-protein dependent pathways. ERK activation pathways can be categorised into two main sub-pathways based on their subcellular localisation Minireview: targeting GPCR activated ERK pathways for drug discovery. Spatiotemporal regulation of the p42/p44 MAPK pathway. Biology of the Cell, 93(1‐2), 71-79.

< GPCR News < GPCRs in Oncology and Immunology Wnt pathway inhibition with the porcupine inhibitor LGK974 The Wnt signaling pathway has been implicated in the pathogenesis of FD-like bone, but the specific Wnts Treatment with the porcupine inhibitor LGK974, which blocks Wnt signaling broadly, induced partial resorption in a mouse model of Gs-GPCR pathway overactivation." pathway inhibition , fibrotic bone disease , fibrous dysplasia (FD) , osteoblasts , trabecular bone

< GPCR News < GPCRs in Oncology and Immunology GPR56 signaling pathway network and its dynamics in the mining of the molecular events plausibly associated with GPR56 activity, we have constructed a signaling pathway , integrin, calcium signaling, growth factors, and inflammation signaling pathways. We also considered intracellular and extracellular factors that may influence the activity of the pathway Raksha A Ganesh , Krishnan Venkataraman , Ravi Sirdeshmukh Tags GPR56 /ADGRG1 , Mesenchymal transition , Pathway

< GPCR News < GPCRs in Oncology and Immunology GPR68-ATF4 signaling is a novel prosurvival pathway in of GPR68 named Ogremorphin (OGM) to induce the iron mediated cell death pathway: ferroptosis. survival assays, via nuclei counting and cell titer glo, were used to demonstrate sensitivity to GPR68 inhibition To determine GPR68 inhibition's mechanism of cell death we use DAVID pathway analysis of RNAseq. In this context, GPR68 suppresses ATF4, inhibition of GPR68 increases expression of ATF4 which leads