April 2022 Sosei Heptares Confirms Senior Leadership Changes to Drive the Company Through the Next Stage Sosei Group Corporation (“the Company”; TSE: 4565) today confirms that a series of Executive Management changes

Obesity-induced changes in human islet G protein-coupled receptor expression: Implications for metabolic

In this study Xin Cai et al. highlight the importance of GPCR dimers in drug discovery referring to important conformational changes, allosteric properties, ligand and functional selectivity. But what are the conformation changes that drive GPCR dimerization? The interaction between two receptors in a dimer involves a conformational change in the transmembrane Interestingly, the amplitude of the conformational changes due to ligand binding is limited at these

Authors Ying Bai , Xin Zhang , Jiawei Zhou , Jianqiang Guo , Yafeng Liu , Chao Liang , Wenyang Wang ,

Authors Pedram Shafiei-Jahani, Shi Yan, Mohammad H Kazemi, Xin Li, Amitis Akbari, Kei Sakano, Yoshihiro

and objectives: The concentrations of adrenocorticotropic hormone and cortisol in plasma, as well as changes pathways related to inhibitory Gi-mediated G protein-coupled receptor (Gi-GPCR) neurons and neuropeptide changes genes: Ciart, per2, per3, cry1, and cry2) were enriched in cortisol secretion and circadian rhythm changes Authors Hong Zeng , Li Cheng , De-Zhi Lu , Shuai Fan , Ke-Xin Wang , Li-Li Xu , Bin Cai , Mou-Wang Zhou