September 2022 "The G-protein-coupled bile acid receptor, Gpbar1 or TGR5, is characterized as a membrane receptor specifically activated by bile acids. effects in different cancer cells upon activating via TGR5 agonists, such as INT-777, ursodeoxycholic acid (UDCA), and taurolithocholic acid (TLCA).

Lysophosphatidic acids (LPAs) are bioactive phospholipids implicated in a wide range of cellular activities

potential targets for drug discovery, however, their role in oncology is underappreciated and GPCR-based We identified gambogic acid (GA), a natural prenylated xanthone, selectively targeting GPR108.

) are proton-activated G protein-coupled receptors that are stimulated upon increased extracellular acidity These receptors have various physiological and pathophysiological roles in renal acid-base physiology , Nicole Joller , Carsten A Wagner , Pedro Henrique Imenez Silva Tags G-protein-coupled receptors , acid-base

difficult highlighting an urgent need for new biomarkers that distinguish ductal carcinomas on this basis For baseline phenotypic characterization, blood gas analysis showed no differences in blood pH, blood demonstrated no differences in fluid intake, urine volume, urinary pH or urine osmolality between genotypes in baseline will be useful to delineate the collecting duct-specific role of GPR56 for renal function, including acid-base sodium/hydrogen exchanger 3 in the intestine and kidneys for fluid and electrolyte homeostasis and acid-base

Oncology and Immunology GPR68-ATF4 signaling is a novel prosurvival pathway in glioblastoma activated by acidic A defining hallmark of GBM is a highly acidic tumor microenvironment, which is thought to activate pro-tumorigenic Notably GPR68, an acid sensing GPCR, is upregulated in radioresistant GBM. identified in a non-biased zebrafish embryonic development screen and validated with Morpholino and CRISPR based demonstrate how glioblastoma cells acidify their microenvironment to activate the commonly over expressed acid