studies show that β-arrestin1 drives tauopathy by destabilizing microtubules and impeding p62/SQSTM1 autophagy

for complete autophagy. Inhibition of autophagy by 3-methyladenine or interference of ATG5 or ATG7 attenuated HBx-induced cell The absence of autophagy abolished the phosphorylation of CDK2 and the activity of the CDK2-CCNE1 complex Our results demonstrate that ARRB1 plays a critical role in HBV-related HCC via modulating autophagy related 5; ATG7: autophagy related 7; Baf A1: bafilomycin A1; CDK2: cyclin dependent kinase 2; CDKN1B

taste receptor agonists attenuate macrophage IL‐1β expression and eosinophilic inflammation linked to autophagy Autophagy deficiency in myeloid cells plays a causal role in eosinophilic CRS (ECRS) via macrophage IL ‐1β overproduction, thereby suggesting autophagy regulation as a potential therapeutic modality. Trehalose is a disaccharide sugar with known pro‐autophagy activity and effective in alleviating diverse We sought to investigate the therapeutic potential of autophagy‐enhancing agent, trehalose, or related

News < GPCRs in Oncology and Immunology RGS20 promotes non-small cell lung carcinoma proliferation via autophagy Western blotting demonstrated different expressions of autophagy and the Hippo-PKA signal pathway. Further, RGS20 accelerated cell proliferation by increasing autophagy. Remarkably, inhibiting Hippo signaling with GA-017 promoted cell proliferation and activated autophagy Conclusion: Our findings indicate that RGS20 drives NSCLC cell proliferation by triggering autophagy

cellular protein that has turned out to be very relevant in the control of the cellular process known as autophagy been published in the journal Nature Communications (12 (1):4540, 2021) with the title "Gαq controls autophagy

where I started working on membranes and membrane protein biochemistry by studying membrane fusion and autophagy