Whether you are a healthcare professional, researcher, or student in the life sciences, this course will

August 2022 Deciphering the signaling mechanisms of β-arrestin1 and β-arrestin2 in regulation of cancer cell cycle and metastasis "β-Arrestins are ubiquitously expressed intracellular proteins with many functions They have participated in various cellular processes such as cell proliferation, migration, apoptosis physiological processes, these activities are also involved in the onset and progression of various cancers processes has important implications for understanding the therapeutic intervention and treatment of cancer

September 2022 GASP1 enhances malignant phenotypes of breast cancer cells and decreases their response cells, such as inhibition of cell proliferation, colony formation, migration, invasion and xenograft tumor growth in nude mice as well as induction of G1-phase cell cycle arrest, and vice versa. Besides, we found that GASP1 knockout obviously improved the response of breast cancer cells to paclitaxel Collectively, this study demonstrates that GASP1 enhances malignant behaviors of breast cancer cells

October 2022 Identification of A2BAR as a potential target in colorectal cancer using novel fluorescent Here, using colorectal cancer (CRC) as a model, we explored the gene expression of a panel of GPCRs in We selected the adenosine receptor 2B (A2BAR), specifically expressed in cancer cell lines compared with Fluorescent probes allowed semi-quantitative receptor mapping in living cells and validated the specific expression of A2BAR in CRC cell lines.

and Immunology [1,2,4]Triazolo[1,5-c]pyrimidines as Tools to Investigate A3 Adenosine Receptors in Cancer Cell Lines Published date September 7, 2023 Abstract "A3 adenosine receptor is an interesting target that showed controversial roles in cancer. Compound 20 has been tested on both A3 adenosine receptor positive cancer cell lines (CHO-A3AR transfected , THP1 and HCCT26) and in A3 negative cancer cell lines, showing no effect on the latter and a proliferative

GPCRs in Oncology and Immunology Autocrine proteinase-activated receptor signaling in PC3 prostate cancer cells Published date June 29, 2023 Abstract "Proteinase-activated receptors (PARs) are G protein-coupled PARs are highly expressed in many cancer cells, including prostate cancer (PCa), and regulate various In this study, we examined the androgen-independent human prostatic cancer cell line PC3 and find the of PAR1 promotes PC3 cell migration and suppresses cell proliferation, whereas PAR2 deficiency showed

overexpressed in various types of cancer and is involved in several cancer phenotypes including tumor Here, we show that HRH1 is widely expressed in various cancer cell lines and cancer tissues and that coexpression of CXCR4 and HRH1 is associated with poor prognosis in breast cancer. while histamine alone does not induce cell migration. Enhanced calcium signaling and cell migration are also observed in NCI-H23 and HeLa cells, which coexpress