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Efferocytes release extracellular vesicles to resolve inflammation and tissue injury via prosaposin-GPR37 signaling
efferocyte-derived EVs express prosaposin, which binds to macrophage GPR37 to increase expression of the efferocytosis receptor Tim4 via an ERK-AP1-dependent signaling axis, leading to increased macrophage efferocytosis efferocyte-derived EVs in a murine model of atherosclerosis is associated with an increase in lesional macrophage efferocytosis Thus, we establish a critical role for efferocyte-derived vesicular mediators in increasing macrophage efferocytosis Austin-Williams , Shantanu Sengupta , Manikandan Subramanian Tags CP: Immunology , GPCR , atherosclerosis , efferocytosis