September 2022 "The activation of phospholipase C (PLC) is thought to have a key role in the cardiomyocyte

Deletion of phospholipase Cβ3 (PLCβ3), or selective inhibition of Gβγ regulation of PLCβ3, enhances the

Here, we provide evidence that distal carboxyl-terminal tail (C-tail), but not proximal, phosphorylation site-directed mutagenesis and bioluminescence resonance energy transfer approaches that distal, not proximal, C-tail In addition, we show that GPCRs that have similarly positioned C-tail phosphoresidues are also able to However, although necessary for some GPCRs, we found that distal C-tail sites might not be sufficient In conclusion, this study provides evidence that distal C-tail phosphorylation sites specify GRK-βarrestin-mediated

Abstract " The current dogma is that chemoattractants G protein-coupled receptors (GPCRs) activate β phospholipase C (PLCβ) while receptor tyrosine kinases (RTKs) activate γ phospholipase C (PLCγ). phospholipase C (PLC) signaling and is essential for neutrophil polarization and migration during chemotaxis protein-coupled receptor (GPCR) , calcium-promoted Ras inactivator (CAPRI) , chemotaxis , neutrophils , phospholipase C (PLC) , g2 phospholipase C (PLCγ2) .

GPCRs in Oncology and Immunology [Inhibitory effect of downregulating G protein-coupled receptor class C 2024 Abstract "Objective: To clarify the effect and the mechanism of G protein-coupled receptor class C

The C. elegans ascaroside-sensing GPCR, SRBC66 and GPCRs of many fungi are also predicted for dual localization An SRBC64/66-GprC chimaeric protein was functional in A. flagrans, and C. elegans SRBC64/66 and DAF38 Authors Xiaodi Hu, David S Hoffmann, Mai Wang, Lars Schuhmacher, Maria C Stroe, Birgit Schreckenberger