The curriculum is divided into four modules, each focusing on essential aspects of pharmacological principles

receptors (GPCRs), including the parathyroid hormone 1 receptor (PTH1R), a class B GPCR and an important modulator activation of PTH1R and its downstream signaling, we describe here that RAMP2 acts as a specific allosteric modulator Moreover, RAMP2 modulates PTH1R downstream signaling in an agonist-dependent manner, most notably increasing Employing homology modeling, we describe the putative structural molecular basis underlying our functional of RAMPs in the activation and signaling of a GPCR that may provide a new venue for highly specific modulation

The mouse cytomegalovirus G protein-coupled receptor homolog, M33, coordinates key features of in vivo Animal models of CMV provide insights into their role in viral fitness. All cytomegalovirus (CMV) genomes analysed to date possess GPCR homologs with phylogenetic evidence for The mouse CMV (MCMV) GPCR homolog, designated M33, is important for cell-associated virus spread and

We designed an integrative approach to improve comparative modeling of TAS2Rs. We constructed accurate homology models of human TAS2Rs. As a test case, we examined the accuracy of the TAS2R16 model with site-directed mutagenesis and in vitro

strategies to express, reconstitute and assay engineered GPCRs using the visual pigment rhodopsin as a model that stemmed from this work, such as the concept of “functional micro-domains” and the “helix movement model Tom’s lab also pioneered the early use of computational homology modeling, molecular dynamics simulations

microglial response in Alzheimer’s disease Xianhua Piao Uncovering the signaling pathway of the ADGRA homolog Xianhua Piao on the web Piao Lab Uncovering the signaling pathway of the ADGRA homolog Remoulade in Drosophila Phylogenetic analysis revealed that the remoulade (remo) gene is a homologue of the vertebrate aGPCR The mammalian Remo homolog ADGRA2/Gpr124 cooperates with other GPCRs of the Frizzled family, and the Langenhan where I am studying and characterizing newly generated adhesion GPCR receptors in Drosophila as a model

GPR50 (G protein-coupled receptor 50) is an orphan GPCR that shares the highest sequence homology with