September 2022 High GPER expression in triple-negative breast cancer is linked to pro-metastatic pathways events ( P  = 0.019) and liver metastasis ( P  = 0.011). At a median follow-up interval of 67.1 months, a significant trend towards reduced distant metastasis-free Besides, high GPER expression was significantly linked to the worse survival in patients with lymph node metastasis Transcriptome-based bioinformatics analysis revealed that GPER was linked to pro-metastatic pathways

organ-specific chemokine receptor, interacts with its exclusive ligand CCL25 to promote tumor proliferation and metastasis

Deciphering the signaling mechanisms of β-arrestin1 and β-arrestin2 in regulation of cancer cell cycle and metastasis

GPCRs in Oncology and Immunology GPR143 controls ESCRT-dependent exosome biogenesis and promotes cancer metastasis Through gain- and loss-of-function studies in mice, we show that GPR143 promotes metastasis by secreting Tags GPR143 , HRS , MVB , breast cancer , exosomal protein sorting , exosome biogenesis , melanoma , metastasis

Olfactory receptors have demonstrated influence over tumor cell proliferation and metastasis, establishing Olfactory receptors , Therapeutic targeting , Tumor cell proliferation , Tumor development , Tumor metastasis

In cancer, chemokines play paradoxical roles in both the directed emigration of metastatic, receptor-expressing Drouillard, Brian T Craig, Michael B Dwinell Tags Chemokine receptor; cell migration; immuno-oncology; metastasis