revealed that in the interactome of VLGR1, molecules are enriched that are associated with both the ER and mitochondria , as well as mitochondria-associated ER membranes (MAMs), a compartment at the contact sites of both resulted in alterations in the MAM architecture and in the dysregulation of the Ca2+ transient from ER to mitochondria

September 2022 GPCR/endocytosis/ERK signaling/S2R is involved in the regulation of the internalization, mitochondria-targeting We recently have shown that fluorescently labeled Hst1 (F-Hst1) targets and activates mitochondria, presenting respiration and Na+/K+-ATPase activity on the uptake, mitochondria-targeting and -activating properties Only the inhibitor of CME and KD of S2R/TMEM97 significantly compromised the mitochondria-targeting of its mitochondria-activating property."

uncouple oxygen intake by the electron transport chain from ATP production in the inner membrane of the mitochondria UCPs are hypothesised to be triggered by superoxide and then reduce mitochondrial free radical production

Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Regulation and role of mitochondria

GPCRs in Oncology and Immunology GprC of the nematode-trapping fungus Arthrobotrys flagrans activates mitochondria However, GprC and GasA also reside in mitochondria and boost respiration.

endomyocardial biopsies were used for histological assessment of cardiomyopathy and determination of cardiac mitochondrial AT2R autoantibodies were associated with improved myocardial mitochondrial coupling as measured by high-resolution haemodynamic, metabolic, and functional markers of disease severity, myocardial histology, and myocardial mitochondrial