revealed that in the interactome of VLGR1, molecules are enriched that are associated with both the ER and mitochondria , as well as mitochondria-associated ER membranes (MAMs), a compartment at the contact sites of both resulted in alterations in the MAM architecture and in the dysregulation of the Ca2+ transient from ER to mitochondria

September 2022 GPCR/endocytosis/ERK signaling/S2R is involved in the regulation of the internalization, mitochondria-targeting We recently have shown that fluorescently labeled Hst1 (F-Hst1) targets and activates mitochondria, presenting respiration and Na+/K+-ATPase activity on the uptake, mitochondria-targeting and -activating properties Only the inhibitor of CME and KD of S2R/TMEM97 significantly compromised the mitochondria-targeting of its mitochondria-activating property."

uncouple oxygen intake by the electron transport chain from ATP production in the inner membrane of the mitochondria UCPs are hypothesised to be triggered by superoxide and then reduce mitochondrial free radical production

Feng , Kangpeng Jin , Xiaowei Wang , Yueming Sun Tags GPCR , autophagy , growth , homology modeling , mitochondria

to Full Agenda Session IV AGPCRs signaling in the nervous system BAI1/ADGRB1-mediated Regulation of Mitochondrial Ligand Interaction In The Adhesion GPCR Latrophilin/Cirl Anne Bormann BAI1/ADGRB1-mediated Regulation of Mitochondrial

His lab was among the first to discover mitochondrial functions of GPCRs.