Here, we demonstrate identification of a pleckstrin-homology (PH)-binding motif within PAR4, critical In addition to PH-Akt/PKB association, other PH-containing signal proteins such as Gab1 and Sos1 also Point mutations are in the C-tail of PAR4 PH-binding domain; F347 L and D349A, but not E346A, abrogate Pc(4-4), a lead backbone cyclic peptide, was selected out of a mini-library, directed toward PAR2&4 PH-binding

The mouse cytomegalovirus G protein-coupled receptor homolog, M33, coordinates key features of in vivo All cytomegalovirus (CMV) genomes analysed to date possess GPCR homologs with phylogenetic evidence for The mouse CMV (MCMV) GPCR homolog, designated M33, is important for cell-associated virus spread and

development of its best-in-class and first-in-class immuno-oncology programs STRASBOURG, France & MONTREAL- Domain

< GPCR News < GPCRs in Oncology and Immunology Involvement of Protease-Activated Receptor2 Pleckstrin Homology Binding Domain in Ovarian Cancer: Expression in Fallopian Tubes and Drug Design Published date Previously we identified pleckstrin homology (PH) binding domains within PAR1,2&4 as critical sites for Pc(4-4) binds to the PAR PH binding domain and blocks the association of PH-signal proteins, such as homology (PH) domain , protease-activated receptors (PARs) Source Contribute to the GPCR News Coming

and pathological roles of AGPCRs in the nervous system Uncovering the signaling pathway of the ADGRA homolog To Control Germ Cell Proliferation Willem Berend Post Uncovering the signaling pathway of the ADGRA homolog ADGRA family, sharing the same overall receptor domain structure. Hence, Remo is proteolytically processed, either by the GAIN domain or an alternative protease that cleaved The mammalian Remo homolog ADGRA2/Gpr124 cooperates with other GPCRs of the Frizzled family, and the

< GPCR News < GPCRs in Oncology and Immunology GPR4 in the pH-dependent migration of melanoma cells in Membrane-bound receptors, such as the proton-sensitive GPCR (pH-GPCR) GPR4, are considered as potential In this study, we investigated the pH-dependent migration of GPR4 wildtype/overexpressing SK-Mel-28 cells Migration of GPR4 overexpressing SK-Mel-28 cells was enhanced in a range of pH 6.5 - pH 7.5 as compared setup, but not at pH 6.5.