Search Results

Modules: Module 1 - Concentration-response analysis: Become a CRC super-user Module 2 - Quantifying

October 2022 Dimerization of β2-adrenergic receptor is responsible for the constitutive activity subjected Here, we revealed that dimerization of β2-AR is responsible for the constitutive activity of β2-AR generating

September 2022 "The endocannabinoid system plays a key role in the intersection of the nervous, endocrine, and immune systems, regulating not only their functions but also how they interplay with each other. Endogenous ligands, named endocannabinoids, are produced “on demand” to finely regulate the synthesis and secretion of hormones and neurotransmitters, as well as to regulate the production of cytokines and other proinflammatory mediators. It is well known that immune challenges, such as exposure to lipopolysaccharide, the main component of the Gram-negative bacteria cell wall, disrupt not only the hypothalamic–pituitary–adrenal axis but also affects other endocrine systems such as the hypothalamic–pituitary–gonadal axis and the release of oxytocin from the neurohypophysis. Here we explore which actors and molecular mechanisms are involved in these processes." Read more at the source #DrGPCR #GPCR #IndustryNews

In CD8 + T cells, the chemokines promote unique transcriptional responses predicted to regulate inflammatory Our work demonstrates that differential subcellular signaling is critical to the overall biased response

to progesterone: a study based on RNA-seq Published date August 8, 2023 Abstract "Background: About one-third of patients with estrogen receptor alpha (ERα)-positive breast cancer have tumors which are progesterone New evidence has shown that progesterone (P4) has an anti-proliferative effect in ERα-positive breast Eduardo , Irene Keller , Nathalie Schuster , Stefan Aebi , Rolf Jaggi Tags Breast cancer cell pools , progesterone response , RNA-seq , CRISPR/Cas9 , estrogen receptor alpha , gene expression , Progesterone receptor

instance, membrane receptor GPR97 is able to sense glucocorticoid to mediate its rapid actions, the progesterone

< GPCR News < GPCRs in Oncology and Immunology Ultrasensitive dose-response for asbestos cancer risk In contrast, a linear no-threshold (LNT) dose-response relationship is expected for damage that accumulates both, rendering ambiguous expectations concerning the nature of model-implied shape of the low-dose response somatic mutations) of the most efficient pathway to any type of cancer in any reparable tissue (Dose-Response