September 2022 Endothelin-1 Stimulates PAI-1 Protein Expression via Dual Transactivation Pathway Dependent expression of PAI-1 induced by endothelin-1 (ET-1) in bovine aortic endothelial cells (BAECs). Moreover, ET-1-increased protein expression of PAI-1 was decreased in the presence of bosentan (ET receptor expression of PAI-1<br />via induced the transactivation pathways of EGFR and TGFR. This study is the first attempt to scrutinize the significant role of ROCK in the protein expression

October 2022 "We describe production of the human A2A adenosine receptor (A2AAR), a class A G protein-coupled We explain in detail steps shared between the two sample preparation strategies, including expression

Biosensors for monitoring G protein-coupled receptors (GPCRs), the most drugged class of proteins in Their applications have continually expanded our understanding of this important protein class.

After 2-24 h, brains were collected for the analysis of gene expression by RT-PCR or protein expression and 12 h for protein analysis. GPR110 ligand decreased the mRNA and/or protein expression of these cytokines and Iba-1 in the WT but PDE4B expression at both mRNA and protein level in the brain increased after ethanol and LPS treatment while synaptamide suppressed its expression in a GPR110-dependent manner.

chemerin is the endogenous ligand of the chemokine-like receptor 1 (CMKLR1), a member of the family of G protein-coupled This protein ligand plays an important role in obesity and inflammatory processes. Using receptor chimera of G protein-coupled receptor 1 (GPR1) and CMKLR1, we were able to identify the Tags double mutant cycle analysis , protein expression , protein-protein interaction , receptor binding

< GPCR News < GPCRs in Oncology and Immunology Expression pattern and clinical significance of beta 2 The present study aimed at investigating the β2-AR gene expression and its significance in relation with Results: Out of the total of 65 OSCC tissues, 41 tissues (63.1%) exhibited high expression for β2-AR protein. High β2-AR protein expression was significantly associated with multiple risk habits (p = 0.045), histological