March 2022 ERNEST has established an Emergency Fund for Ukrainian researchers. "General Eligibility Researchers affiliated to any legal entity in Ukraine (for example, schools and universities, research centers, governmental institutions, or private companies) Deadlines Start of the project: now End of the project: 31 October 2022 SHORT-TERM SCIENTIFIC MISSIONS (STSM) We offer short-term scientific mission grants to Ukrainian researchers who have been recently displaced by the war, or those who can travel to institutions participating in ERNEST COST Action. The purpose of the STSM is to carry out a collaborative research project on topics relevant to the network. Our scientific perspective is broad, and we are happy to consider any research proposals from those in need." Read more at the source #DrGPCR #GPCR #IndustryNews

August 2022 Deciphering the signaling mechanisms of β-arrestin1 and β-arrestin2 in regulation of cancer which interact directly and indirectly with a wide number of cellular partners and mediate downstream signaling adaptor proteins that control the recruitment, activation, and scaffolding of numerous cytoplasmic signaling complexes and assist in G-protein receptor signaling, thus bringing them into close proximity. This review delivers a concise overview of the role of β-arrestins with a primary emphasis on the signaling

September 2022 "GPCR signaling and function depend on their associated proteins and subcellular locations they connect a large number of diverse proteins to form signaling networks. We found that some agonist-induced GPCR/14-3-3 signal intensities can rapidly decrease. could also be paralleled with GPCR/β-arrestin-2 signals, indicating diminished levels of GPCR/signal a new approach for GPCR drug development by modulating GPCR/14-3-3 signals temporally."

transduction Published date September 1, 2023 Abstract "CCN1 and CCN2 are matricellular proteins that CCN proteins act to facilitate signaling events involving extracellular matrix proteins. Inducible CCNs can potentially play roles in downstream signal transduction events required for LPA and transduction pathways, contributing to the biphasic delayed responses typically seen in response to In this way, an extracellular signal (LPA or S1P) can activate GPCR-mediated intracellular signaling

Angers is an expert in the field of signal transduction. transduction. Moon , where he identified and characterized novel components of the Wnt signaling pathway and a new He is the recipient of the Canada Research Chair in Functional Architecture of Signal Transduction. families of growth factors and their signaling mechanisms in development, adult tissue homeostasis,

It turns out that it was signal transduction, and he worked on the signaling cascades involved in heart His encounter and interest in signaling in the context of GPCRs during his postdoctoral training in Dr Today, John and his team focus on understanding how signal transduction cascades downstream of the opioid receptors work, including the unique organization of chaperone protein Hsp90 modulation of opioid signaling