ACKR3 has been described as an atypical "biased" receptor because it does not appear to signal through of ACKR3 in the CXCL12/CXCR4/ACKR3-signaling axis and better understand the structural determinants for ACKR3 activation. these small molecules and ACKR3 was defined. This work will help to better understand the unique signaling roles of ACKR3."

CKRs can be classified into typical CKRs, atypical CKRs (ACKRs) which lack G-protein signaling, and viral Constitutive Activity of the viral CKR US28 and “Chemokine Scavenger” ACKR3 Both US28 and ACKR3 are constitutively US28 evolved high constitutive activity to evade host immunity, whereas ACKR3 functions as a homeostatic In ACKR3, the presence of a tyrosine at position 6.40 plays a role in its constitutive activity (Yen, However, the role of chemokine ligands in activating US28 and ACKR3 cannot be confirmed without inactive-state

angiotensin II type 2 receptor may prevent colorectal cancer Distinct Activation Mechanisms of CXCR4 and ACKR3

The team’s projects are devoted to the activation/function of CXCR4-ACKR3 (CXCR7) receptors of the CXCL12 chemokines and their receptors, for which she made important breakthroughs regarding the CXCL12/CXCR4/ACKR3 FB’ team has identified the orphan CXCR7/ACKR3 receptor as being the 2nd receptor for CXCL12, which behaves receptors (including CXCR4), and a smaller subgroup of atypical chemokine receptors (including the CXCR7/ACKR3

the non-canonical signaling effectors involved in the activation of Atypical Chemokine Receptor 3 (ACKR3

biased agonism, with the development of approaches to quantify ligand bias and the identification of ACKR3