Bandekar with help from Nathan Zaidman and Abhishek K. Singh

In 2017, Gupte et al. introduced GPCR priming, which posits that non-cognate G proteins can enhance the Gupte et al. utilized a systematic protein affinity strength modulation (SPASM) technique to show that Gupte, T.M., et al., Priming GPCR signaling through the synergistic effect of two G proteins.