August 2022 A NanoBRET-Based H 3 R Conformational Biosensor to Study Real-Time H 3 Receptor Pharmacology

April 2022 Trevena Receives up to $40M in OLINVYK ex-US Royalty-Based Financing from R-Bridge Healthcare disorders, today announced that the Company entered into a royalty-based financing with an affiliate of R-Bridge Healthcare Fund (the R-Bridge Financing)."

biosensors reveals distinct conformational signatures of β-arrestin1 and 2 when bound to active PTH1R (P-R* specifically by proximal and distal C-terminal phosphorylation and in the absence of GPCR kinases (GRKs) (R* Here, we show differences between conformational changes that are induced by P-R* or R* receptor states

article on Illuminating GPCR Research: FRET and BRET-Based Sensors Shed Light on Cellular Signaling Abigail Walker, Aylin Hanyaloglu, et al., for their study on Constitutive internalisation of EP2 differentially

United States. https://www.genome.gov/ Dixon, R. A., Kobilka, B. K., Strader, D. J., Benovic, J. D., Rands, E., Diehl, R. E., Mumford, R. A., Slater, E. E., Sigal, I. S., Caron, M. ., Lefkowitz, R. J., & Strader, C. D. (1986). Nature, 321(6065), 75–79. https://doi.org/10.1038/321075a0 Fredriksson, R., Lagerström, M.

., Ribeiro-Oliveira, R., Vieira-Rocha, M. S., Vojtek, M., Sousa, J. B., & Diniz, C. (2021). Traffic (Copenhagen, Denmark), 20(7), 465–478. https://doi.org/10.1111/tra.12649 Ribeiro-Oliveira, R. N., Castro, M., Wang, B., Bouley, R., Potts, J. T., Gardella, T. J., & Vilardaga, J. P. (2009). M., & Lefkowitz, R. J. (2003). E., French, R. P., Lowy, A. M., & Murray, F. (2018).

of First $15 million Tranche in Connection with its $40 million ex-US Royalty-Based Financing with R-Bridge receipt of the first $15 million tranche from its royalty-based financing agreement with an affiliate of R-Bridge Healthcare Fund (the R-Bridge Financing)."

Premont, R. T. & Gainetdinov, R. R.

assays for the functional characterization of (psychedelic) substances at the serotonin receptor 5-HT2A R techniques that have been used the most abundantly for the characterization of (psychedelic) 5-HT2A R

Sugiura, R., Satoh, R., & Takasaki, T. (2021). ERK: a double-edged sword in cancer. M., & Lefkowitz, R. J. (2003).

maintaining the responsiveness of canonical G protein-coupled CKRs that bind to the same ligand(s) (Nibbs, R. instance, CCR2 inhibition leads to inhibition of scavenging and elevated plasma levels of CCL2 (Aiello, R.

Di Roberto, R. B., Chang, B., & Peisajovich, S. G. (2017). Kosar, M., Sarott, R. C., Sykes, D. A., Viray, A. E., Vitale, R.

., Sunahara, R. K., Gellman, S. H., Pautsch, A., Steyaert, J., Weis, W. I., & Kobilka, B. R., Venkatakrishnan, A. J., Jude, K. M., Dukkipati, A., Feinberg, E. ., Dror, R. O., Ploegh, H. L., & Garcia, K. C. (2015). Structural biology.

Improving Hematopoietic Stem Cell Mobilization Using Propranolol with GPC-100 Sosei Heptares to Host R& D Day Highlighting its Innovative R&D and Late-Stage Development Progress Parker Moss to Join Exscientia

Multi-target Collaboration and License Agreement in Diabetes and Metabolic Diseases Sosei Heptares Enters R& Treating Type 2 Diabetes and Obesity Special report 2022: Meet 20 women blazing trails in biopharma R&

differentially expressed genes (DEGs) and weighted correlation network analysis (WGCNA) were performed using R

R ead more at the source #DrGPCR #GPCR #IndustryNews

., and Head of UK R&D Tokyo, Japan and Cambridge, UK, 24 March 2022 – Sosei Group Corporation (“the

. & Kyle, R. A. Sir Bernard Katz--winner of Nobel Prize in physiology or medicine. C. & Bond, R. A. Sir James Whyte Black OM. 14 June 192422 March 2010. Eric R. Chemistry, R. S. of. R. B. & Irannejad, R.

conformation-selective probes for monitoring activation-induced changes in cellular environments (Irannejad, R. conformational changes for the binding to the same GPCR to mediate differential regulatory effects (Haider, R. various processes, and their imbalance is linked to pathological conditions, including cancer (Gros, R.

., Mistry, R., Goulding, J., Drube, J., Hoffmann, C., Owen, D. M., Shukla, A. Cell, 186(10), 2238–2255.e20. https://doi.org/10.1016/j.cell.2023.04.018 Janetzko, J., Kise, R., Barsi-Rhyne

responsiveness of canonical G protein–coupled chemokine receptors that bind to the same ligand(s) (R. Wang et al. 2009; R. J.

Receives US$10 Million from AbbVie as Collaboration Targeting Neurological Diseases Achieves First R&

., and R. Schekman. 2008. Membrane fusion. Nat. Struct. Mol. Biol. 15:658–664.

GPCR Binders, Drugs, and more Discovery of SYD5115, a novel orally active small molecule TSH-R antagonist

Releases First Protein Structures in PDB, Advances Lupus Therapy Research Structure Therapeutics Receives R&

Janicot, R., et al., Direct interrogation of context-dependent GPCR activity with a universal biosensor

This week's highlight includes congrats to: Madison Walker , Benjamin Myers , et al., for their research