Experimental approach: COS-7 cells were transfected with the human GLP-2R and assessed for cAMP accumulation To examine selectivity, COS-7 cells expressing human GLP-1 or GIP receptors were assessed for cAMP accumulation

Increased β-arrestin1 in turn drives the accumulation of pathogenic tau, whereas reduced ARRB1 alleviates impeding p62/SQSTM1 autophagy flux by interfering with p62 body formation, which promotes pathogenic tau accumulation

The above causes β-arrestin molecules to stay longer and accumulate on the plasma membrane, allowing β-arrestin molecules and the time they spend diffusing on the plasma membrane leads to their recruitment and accumulation tethered to CCPs bind receptors diffusing on the plasma membrane, also causing their recruitment and accumulation

ATP functions as a mighty damage-linked molecular pattern when released outside the cell, accumulating

Tcf21+ α-smooth muscle actin (α-SMA)+ interstitial cells accumulated in the kidneys of mice with UUO

Results: We identified that knockout and VSMC-specific knockdown of RGS5 exacerbated accumulation and