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22 items found for "Accumulation"
Posts (17)
- N-terminal alterations turn the gut hormone GLP-2 into an antagonist with gradual loss of GLP-2 ...
Experimental approach: COS-7 cells were transfected with the human GLP-2R and assessed for cAMP accumulation To examine selectivity, COS-7 cells expressing human GLP-1 or GIP receptors were assessed for cAMP accumulation
- β-arrestin1 promotes tauopathy by transducing GPCR signaling, disrupting microtubules and autophagy
Increased β-arrestin1 in turn drives the accumulation of pathogenic tau, whereas reduced ARRB1 alleviates impeding p62/SQSTM1 autophagy flux by interfering with p62 body formation, which promotes pathogenic tau accumulation
- Unlocking Cell's Secrets: Spontaneous β-Arrestin-Membrane Preassociation Drives Receptor-Activation
The above causes β-arrestin molecules to stay longer and accumulate on the plasma membrane, allowing β-arrestin molecules and the time they spend diffusing on the plasma membrane leads to their recruitment and accumulation tethered to CCPs bind receptors diffusing on the plasma membrane, also causing their recruitment and accumulation
Other Pages (5)
- Metallo-protease Peptidase M84 from Bacillusaltitudinis induces ROS-dependent apoptosis in ovarian cancer cells by targeting PAR-1
intraperitoneal administration of Peptidase M84 in syngeneic mice significantly diminished ascites accumulation
- Metabolic crosstalk: Extracellular ATP and the tumor microenvironment in cancer progression and therapy
ATP functions as a mighty damage-linked molecular pattern when released outside the cell, accumulating
- GPR97 depletion aggravates imiquimod-induced psoriasis pathogenesis via amplifying IL-23/IL-17 axis signal pathway
In addition, hyperproliferative keratinocytes as well as accumulation of DCs and Th17 cells were detected