Experimental approach: COS-7 cells were transfected with the human GLP-2R and assessed for cAMP accumulation To examine selectivity, COS-7 cells expressing human GLP-1 or GIP receptors were assessed for cAMP accumulation

Increased β-arrestin1 in turn drives the accumulation of pathogenic tau, whereas reduced ARRB1 alleviates impeding p62/SQSTM1 autophagy flux by interfering with p62 body formation, which promotes pathogenic tau accumulation

The above causes β-arrestin molecules to stay longer and accumulate on the plasma membrane, allowing β-arrestin molecules and the time they spend diffusing on the plasma membrane leads to their recruitment and accumulation tethered to CCPs bind receptors diffusing on the plasma membrane, also causing their recruitment and accumulation

Accumulative evidence shows that the location of signaling has an impact on the physiological effects

Here, we reveal that the Smog GPCR transduces Fog signal to regulate Rho kinase accumulation and myosin

Here, we reveal that the Smog GPCR transduces Fog signal to regulate Rho kinase accumulation and myosin

is a kind of G protein coupled receptor (GPCR) and mainly couples with Gαs protein leading to cAMP accumulation

canonical G protein signaling pathway (e.g. measuring G protein recruitment/activation, inositol phosphate accumulation

Furthermore, the GPR15 receptor signals through Gi/o to inhibit cAMP accumulation, which could be blocked

MRP extrusion capacity was determined by intracellular 5 (6)-Carboxyfluorescein diacetate (CFDA) accumulation

effects of THC and CBD on the differentiation of MECs by assessing changes in cellular viability, lipid accumulation

Accumulation of inositol monophosphate (IP1) in the frontal cortex upon DOI administration showed no

the nonselective MT1/MT2 agonist ramelteon (10 µM) significantly inhibited forskolin-stimulated cAMP accumulation

Train-dependent presynaptic Ca2+ accumulation forces frequency-dependent recovery of neurotransmission

cAMP signalling, while Gs proteins similarly enhanced Gq dependent-vasopressin receptor-mediated IP1 accumulation

In contrast, exendin-P5, another GLP-1R agonist, is biased towards cAMP accumulation but with reduced

between neuropeptide and neurotransmitter release GPCRs in Oncology and Immunology Neurotoxicity and accumulation

Traditionally, second messenger assays measuring cAMP accumulation, calcium mobilization, and ERK phosphorylation

A1 Receptor GPCRs in Cardiology, Endocrinology, and Taste Ciliary localization of GPR75 promotes fat accumulation