< GPCR News < GPCRs in Oncology and Immunology Neurotoxicity and accumulation of CPPD quinone at environmentally Using Caenorhabditis elegans as an animal model, we here examined neurotoxicity and accumulation of CPPDQ After exposure to 0.01-10 μg/L CPPDQ, obvious body accumulation of CPDDQ was detected. and dcar-1 resulted in susceptibility, and nhr-8 RNAi caused resistance to CPPDQ neurotoxicity and accumulation Authors Xin Wan, Geyu Liang, Dayong Wang Tags Accumulation , C. elegans , CPPDQ , Neurotoxicity Source

Itaconate (ITA) rapidly accumulates to high levels in myeloid cells under infectious and sterile inflammatory

intraperitoneal administration of Peptidase M84 in syngeneic mice significantly diminished ascites accumulation

results suggest that several of the novel small-molecule compounds could inhibit GHRH-induced cAMP accumulation

ATP functions as a mighty damage-linked molecular pattern when released outside the cell, accumulating

Results: We identified that knockout and VSMC-specific knockdown of RGS5 exacerbated accumulation and

Tcf21+ α-smooth muscle actin (α-SMA)+ interstitial cells accumulated in the kidneys of mice with UUO

In contrast, a linear no-threshold (LNT) dose-response relationship is expected for damage that accumulates

In addition, hyperproliferative keratinocytes as well as accumulation of DCs and Th17 cells were detected

alterations in disease progression, OGR1 KO mice had higher urinary calcium levels and exacerbated crystal accumulation

RGS6 was expressed in the cytoplasm and accumulated in the nucleus after LPS stimulation.

In this talk, I summarize accumulating data from our lab and the aGPCR field that suggests an additional

We previously demonstrated that kidney-specific Adgrf5/Gpr116 knockout causes luminal membrane accumulation