GPCR News < GPCRs in Oncology and Immunology Regulator of G protein signaling protein 6 alleviates acute lung injury by inhibiting inflammation and promoting cell self-renewal in mice Published date December 8, 2023 Abstract " Background: Acute respiratory distress syndrome (ARDS) is a disease with high mortality lung injury (ALI) model were identified, and functional enrichment analysis was conducted. lung injury , Apoptosis , Cell-renewal , Inflammation , Regulator of G protein signaling 6 .

atypical p38 signaling responses we are studying how atypical p38 controls the onset and pathogenesis of acute lung injury, retinal vasculopathies, and infections. " Dr.

< GPCR News < GPCRs in Oncology and Immunology Mutation Patterns Predict Drug Sensitivity in Acute Myeloid Leukemia Published date June 14, 2024 Abstract " Purpose: The inherent genetic heterogeneity of acute

GPCRs in Oncology and Immunology Activation of orphan receptor GPR132 induces cell differentiation in acute date November 1, 2022 Abstract Blocked cellular differentiation is a critical pathologic hallmark of acute

Immunology Minireview: functional roles of tissue kallikrein, kinins, and kallikrein-related peptidases in lung Published date July 3, 2023 Abstract "Despite campaigns and improvements in detection and treatment, lung One approach to treating patients suffering from lung cancer is to target surface receptors overexpressed Since lung cancer is often diagnosed in advanced stages, our efforts should focus on early diagnosis, Furthermore, their modulation could be considered as a promising approach in lung cancer therapeutics

Druey at NIAID/NIH, where I characterized the role of RGS4 and RGS5 in airway hyperresponsiveness and lung fibrosis in acute and chronic mouse models of allergic asthma. fascinated by the multitude of processes that are regulated/dysregulated by GPCRs and RGS proteins in the lungs

the Mrgpra1-NPFF axis counter-regulated interferon (IFN) γ-mediated neutrophil polarization during acute lung infection by favoring an alternative-like polarization, suggesting that it may act to balance overzealous Aishwarya Atakkatan , Felipe Andrade , Stephane Lajoie , Xinzhong Dong Tags IFNγ , Mrgpra1 GPCR , NPFF , lung

< GPCR News < GPCRs in Oncology and Immunology Exacerbating effects of single-dose acute ethanol exposure The goal of this study is to determine the effects of single-dose acute ethanol exposure and GPR110 activation

Ovarian cancer G protein-coupled receptor 1 (OGR1) deficiency exacerbates crystal deposition and kidney injury Their function in injured renal tissue, however, remains mostly unclear. When lowering the severity of the kidney injury, OGR1 KO mice were more prone to develop crystalline </p> Taken together, in the acute setting of oxalate-induced nephropathy, the lack of the proton-activated

/2 study of the PLK1 inhibitor onvansertib in combination with decitabine in relapsed or refractory acute myeloid leukemia Published date November 1, 2023 Abstract "PLK1 is overexpressed in acute myeloid leukemia

< GPCR News < GPCRs in Oncology and Immunology A2aR on lung adenocarcinoma cells: A novel target for Here, we identify that A2aR is specifically expressed on tumor cells from lung adenocarcinoma (LUAD) Tags A2aR , Lung adenocarcinoma , Migration , Polarization , Targeted therapy , Tumor-associated macrophages

aspects of GPCR regulation of cardiac function, inflammation and remodeling during HF or following acute cardiac injury. structure and function, and has evolved to encompass their roles in regulating immune cell response to acute cardiac injury or chronic stress.

< GPCR News < GPCRs in Oncology and Immunology RGS20 promotes non-small cell lung carcinoma proliferation Background: Novel therapeutic targets are urgently needed for treating drug-resistant non-small cell lung Methods: Immunohistochemistry and lung cancer tissue microarray were used to verify the expression of the role of RGS20 as a promising novel molecular marker and a target for future targeted therapies in lung

We studied injury-induced immune dysfunction seeking novel means to reverse such predisposition. Predicted rescue therapies were assessed in cell systems and mouse injury-dependent pneumonia models. Either GRK2 or HDAC inhibition prevented loss of mouse lung bacterial clearance, but only the combination rescued clearance when given post-injury. Simultaneous GRK2/HDAC inhibition rescues susceptibility to infection after tissue injury.

G protein-coupled receptor 37 promotes resistance to cisplatin-induced apoptosis in non-small cell lung cancer Published date September 21, 2023 Abstract "Objectives: Lung cancer is a major public health protein-coupled receptor 37 (GPR37) exhibits unknown functions in tumors, particularly in non-small-cell lung Conclusions: It was suggested that GPR37 acts a crucial role in promoting the occurrence and development

Transforming growth factor-β (TGFβ) is essential for alveologenesis and lung repair, and the G protein To understand the role of mesenchymal Gαq/11 in lung development, we generated constitutive (Pdgfrb-Cre suppressed myofibroblast differentiation, altered mesenchymal cell synthetic function, and reduced lung TGFβ2 signalling in mesenchymal cells, which is imperative for normal alveologenesis and maintenance of lung Tags Alveologenesis , Cyclical mechanical stretch , GPCR , Gαq/11 , Lung development , TGFβ .

be used as a biomarker and a new target for diabetes and that CXCR2 antagonists may also attenuate lung injury in coronavirus disease 2019 (COVID-19). " Authors Yishi Xie , Wenbin Kuang , Dawei Wang , Kai

In gene expression analysis of mouse lungs with induced fibrosis, eight GPCRs were identified, showing actin (αSMA), the profibrotic factor transforming growth factor β1 (TGFβ1), and collagen in a human lung Similar to the lung fibrosis model, increased Gpr176 expression was also observed in other organs affected expressed Gpr176 compared to alveolar epithelial cells, endothelial cells, and macrophages in the fibrotic lung Consequently, Gpr176 acts in a profibrotic manner, and inhibiting its activity could potentially prevent

Mesothelioma and lung cancer induced by exposure to carcinogenic (e.g., certain asbestos) fibers in humans to engage in tissue repair does not merely promote cancer, but rather is a requisite co-initiator (acting This theory is reviewed, implications of this theory are discussed in relation to mesothelioma and lung Author Kenneth T Bogen Tags Asbestos , Cytotoxicity , Inflammation , Lung cancer , Mesothelioma , Mutation

Authors Magdalena B Flak , Duco S Koenis , Maria Gonzalez-Nunez , Ana Chopo-Pizarro , Jesmond Dalli Tags Acute

context-dependent compared to the C5aR1, which has received enormous attention for its role in both acute

the crystal structure of the beta2-adrenergic receptor (beta2AR)-G protein complex, team effort with long Our goal is to develop safer beta2AR-selective ligands for the treatment of asthma and acute rescue therapy question regarding the signaling differences in G protein splice forms, specifically the short and long Galpha-s(l), but not Galpha-s(s), regulates extracellularly regulated kinases (ERK), and that this long optimize its potential as a treatment for cocaine abuse, a debilitating disease that would require long-term

inhibitor sorafenib improves event-free survival (EFS) when used with 7 + 3 in adults with newly-diagnosed acute

Monserrat Avila Zozaya "My doctoral research was focused on investigating the cellular effects of missense lung

CXCR6 deficiency lowers TRM cell numbers in the lungs and depletes ILC3s in the lamina propria, impairing Notably, single-cell RNA sequencing of the lung shows a drop in TRM cells in species with CXCR6 loss,

transcriptomic analysis reveals complex neuroendocrine regulatory networks mediated by spinal cord injury-induced immunodeficiency Published date September 30, 2023 Abstract "Background: Spinal cord injury (SCI), which causes loss of sensory and motor function in the body below the level of injury, is a devastating disease SCI-IDS predominantly occurs following injury above the T5 levels and eventually leads to systemic immune (T3-SCI) group and the low-level (T10) spinal cord injury (T10-SCI) group.

Single-cell RNA sequencing on long-bone stromal cells of 9-wk-old male ColI(2.3)+/Rs1+ mice and littermate Authors Hsuan Lung, Kelly L Wentworth, Tania Moody, Ariane Zamarioli, Apsara Ram, Gauri Ganesh, Misun

Oncology and Immunology Efferocytes release extracellular vesicles to resolve inflammation and tissue injury increasing macrophage efferocytosis efficiency and accelerating the resolution of inflammation and tissue injury