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2022 Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane adenylyl cyclases "Mycobacterium tuberculosis adenylyl cyclase (AC) Rv1625c/Cya is an evolutionary ancestor of

toxin B and FZD7 Loss-of-function of GNAL dystonia gene impairs striatal dopamine receptors-mediated adenylyl cyclase/ cyclic AMP signaling pathway The non-nutritive sweetener sucralose increases β-arrestin signaling interaction prediction Structural and Molecular Insights into GPCR Function Structural insights into membrane adenylyl cyclases, initiators of cAMP signaling Molecular mechanism of GPCR spatial organization at the plasma

pH-sensing receptors in colitis GPCRs in Oncology and Immunology Polarizing itch Biochemical pharmacology of adenylyl cyclases in cancer Methods & Updates in GPCR Research A multicolor suite for deciphering population

GPCR Binders, Drugs, and more Adenylyl cyclase 6 plays a minor role in the mouse inner ear and retina

immune-related hub genes in spinal cord injury GPCRs in Oncology and Immunology Biochemical pharmacology of adenylyl cyclases in cancer Olfactory Receptors and Tumorigenesis: Implications for Diagnosis and Targeted Therapy

Unusual phototransduction via cross-motif signaling from Gq to adenylyl cyclase in intrinsically photosensitive

global conformational changes in G protein-coupled receptor kinases The membrane domains of mammalian adenylyl cyclases are lipid receptors Structural insights into endogenous ligand selectivity and activation mechanisms

In the human kidney ORs elicit intracellular Ca2+flux in renal proximal tubule cells via adenylyl cyclase

the kinetics of signaling and the spatial organization of signaling effectors, including G proteins, adenylyl cyclases, and kinases.

phototransduction system highlights the potential roles of phosphodiesterase 6 (PDE6) and guanylate cyclases

Nobel Prize in Physiology or Medicine went to Earl Wilbur Sutherland Jr for discovering the key role of adenylate cyclase, which produces the archetypical secondary messenger cyclic AMP (cAMP), plays in cellular signaling .[20,21] Adenylate cyclase is a major component of the downstream signaling cascade of the cAMP signal

Soluble cyclase-mediated nuclear cAMP synthesis is sufficient for cell proliferation.

Soluble cyclase-mediated nuclear cAMP synthesis is sufficient for cell proliferation.