Structure-guided design of a peripherally restricted chemogenetic system Hye Jin Kang , Brian E Krumm , Adrien Tassou , Bryan L Roth , et al. 🕶 University CheatSheet is here!

several important neurohormonal perturbations, emanating from both the autonomic nervous system and the adrenal The adrenal gland plays an important role in the modulation of cardiac neurohormonal stress because it Synthesis and release of these hormones in the adrenals is tightly regulated by adrenal G protein-coupled In this review, we discuss important aspects of adrenal GPCR signaling and regulation, as they pertain to modulation of cardiac function in the context of chronic HF, by focusing on the 2 best studied adrenal

2022 Neurocrine Biosciences Presents Data on Treatment of Adolescent Patients with Classic Congenital Adrenal present new Phase 2 data on the use of crinecerfont in adolescent patients with classic congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21-OHD), which demonstrated substantial reductions in adrenal

medullary axis and the hypothalamic‒pituitary‒adrenal (HPA) axis. Second, the differential regulation of the gene network between the sympathetic-adrenal medullary axis The level of cortisol, which is mediated by the adrenal glands, was markedly elevated, but norepinephrine The upregulated genes in the adrenal glands (hub genes: Ciart, per2, per3, cry1, and cry2) were enriched Disruption of the connection between the hypothalamus and the adrenal glands causes autonomous regulation

receptor (GPCR) expression is highly prevalent in cortisol-secreting primary bilateral macronodular adrenal show that the regulation of endocrine tumours by aberrant GPCR is not restricted to cortisol-secreting adrenal

Immunology Clinical, pathophysiologic, genetic and therapeutic progress in Primary Bilateral Macronodular Adrenal