regulates ischaemia-reperfusion injury GPCRs in Cardiology, Endocrinology, and Taste RGS4 controls airway hyperresponsiveness through GAP-independent mechanisms Phenylacetyl glutamine (PAGln) enhances cardiomyocyte

We investigated whether melatonin receptors are expressed on airway smooth muscle; whether they regulate intracellular cyclic AMP (cAMP) and calcium concentrations ([Ca2+]i), which modulate airway smooth muscle tone; and whether they promote airway smooth muscle cell proliferation. and protein expression of the melatonin MT2 but not the MT1 receptor in native human and guinea pig airway These findings suggest that the melatonin MT2 receptor is expressed in ASM, and modulates airway smooth

activity-modifying proteins Molecular mechanism of bitter taste receptor agonist-mediated relaxation of airway

Kirk Druey at NIAID/NIH, where I characterized the role of RGS4 and RGS5 in airway hyperresponsiveness a side project by which I characterized the impact of a fungal allergenic source on the function of airway

inflammation, sensitization to pruritogens, and itch amplification in atopic dermatitis and prurigo nodularis; airway inflammation/hyperresponsiveness, loss of expiratory volume, airflow obstruction and increased mucus Tags ABPA , ACh , AD , ADCC , AFR , AHR , AR , ASM , Acetylcholine , Airway hyperresponsiveness , Airway

targeting CD97 in glioblastoma Gabriela Aust Critical role for CD97/ADGRE5 in the induction of allergic airway