We investigated whether melatonin receptors are expressed on airway smooth muscle; whether they regulate intracellular cyclic AMP (cAMP) and calcium concentrations ([Ca2+]i), which modulate airway smooth muscle tone; and whether they promote airway smooth muscle cell proliferation. smooth muscle and cultured human airway smooth muscle (HASM) cells by RT-PCR, immunoblotting, and immunohistochemistry These findings suggest that the melatonin MT2 receptor is expressed in ASM, and modulates airway smooth

activity-modifying proteins Molecular mechanism of bitter taste receptor agonist-mediated relaxation of airway smooth muscle GPCR Binders, Drugs, and more Expanding Structure-Activity Relationships of Human Urotensin

multi-graph convolutional network GPCRs in Cardiology, Endocrinology, and Taste Dissecting a Brake for Airway Smooth Muscle Cell Movement Hepatic extracellular ATP/adenosine dynamics in zebrafish models of alcoholic

Kirk Druey at NIAID/NIH, where I characterized the role of RGS4 and RGS5 in airway hyperresponsiveness a side project by which I characterized the impact of a fungal allergenic source on the function of airway smooth muscle cells.

inflammation, sensitization to pruritogens, and itch amplification in atopic dermatitis and prurigo nodularis; airway Tags ABPA , ACh , AD , ADCC , AFR , AHR , AR , ASM , Acetylcholine , Airway hyperresponsiveness , Airway smooth muscle , Allergic bronchopulmonary aspergillosis , Allergic fungal rhinosinusitis , Allergic

Among them, we focused on Gpr176 owing to its significant correlation with a myofibroblast marker α-smooth muscle actin (αSMA), the profibrotic factor transforming growth factor β1 (TGFβ1), and collagen in a