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< GPCR News < GPCRs in Oncology and Immunology The GPCR-Gαs-PKA signaling axis promotes T cell dysfunction cancer types and identified an enrichment of Gαs-coupled GPCRs on exhausted CD8+ T cells. These include EP2, EP4, A2AR, β1AR and β2AR, all of which promote T cell dysfunction. Authors Victoria H Wu , Bryan S Yung , Farhoud Faraji , Robert Saddawi-Konefka , Zhiyong Wang , Alexander T Wenzel , Miranda J Song , Meghana S Pagadala , Lauren M Clubb , Joshua Chiou , Sanju Sinha , Marin

Alexander S. Hauser About Dr. Alexander S. Hauser Alexander is currently a postdoc as a member of the personalized medicine cluster in Copenhagen Alexander has a big interest in the integration of large biomedical data in genomics, structural biology Alexander had a research sabbatical with Madan Babu at the MRC Laboratory of Molecular Biology in Cambridge Alexander S.

therapy (CAR-T), bispecific-antibodies (BsAb) and antibody-drug-conjugates (ADC). Amongst 256 patients, 92 received CAR-T, 55 BsAb and 109 ADC. The incidence of severe infections was higher with BsAb (40%) than CAR-T (26%) or ADC (8%), including with CAR-T compared to BsAb at 1-year (incidence-rate-ratio [IRR] = 0.43, 95%CI 0.25-0.76, P = 0.004 Carlyn Rose Tan, Malin Hultcrantz, Sergio A Giralt, Saad Z Usmani, Zainab Shahid, Sham Mailankody, Alexander

Peter has been chaired Full Professor of Pharmaceutical / Medicinal Chemistry at the Friedrich-Alexander Group "Medicinal Chemistry of Selective GPCR Ligands" (GRK 1910). " Peter Gmeiner on the web Friedrich Alexander

< GPCR News < GPCRs in Oncology and Immunology GPR15 expressed in T lymphocytes from RA patients is involved of synovial fluid and peripheral blood were analyzed for CD45+CD3+CD4+GPR15+ and CD45+CD3+CD8+GPR15+ T Statistical analysis included Kruskal-Wallis test, T-test, or Mann-Whitney U test, according to data Also, the frequency CD4+/CD8+ GPR15+ T lymphocytes are higher in synovial fluid of established RA patients Tags C10ORF99; GPR15; GPR15L; T lymphocytes; chemotaxis; rheumatoid arthritis; synovium.

< GPCR News < GPCRs in Oncology and Immunology A GPCR checkpoint drives CD8+ T cell dysfunction and immunotherapy

RNAi library screening reveals Gβ1, Casein Kinase 2 and ICAP-1 as novel regulators of LFA-1-mediated T and migration Published date November 28, 2024 Abstract "The αLβ2 integrin LFA-1 plays a key role in T-cell cell line model of LFA-1-stimulated T-cell migration. and pathway analysis, three of these genes were characterized in further detail using primary human T and provides potential novel targets for modulation of the T-cell immune response."

receptors induces IFN-γ but suppresses IL-2 production by inhibiting activation of pAKT pathways in primary T to activate the phosphatidylinositol pathway and induce interleukin-2 production in Jurkat leukemic T that activating the pAKT pathway is critical for IL-2 production in T cells." Authors Trang T T Nguyen , Wen Lu , Wandi S Zhu , K Mark Ansel , Hong-Erh Liang , Arthur Weiss . Tags GPCR; T cells; muscarinic receptor; signaling.

< GPCR News < GPCRs in Oncology and Immunology The EBI2 receptor is coexpressed with CCR5 in CD4+ T cells Methods: We identified GPCRs expressed in primary CD4+CCR5+ T cells by multi-RT-qPCR. Results: We showed that EBI2 is naturally expressed in primary CD4+CCR5+ T cells, and that CCR5 and EBI2 in blood and lymphoid tissues, the constant EBI2 activation might increase HIV replication in CD4+ T

Immunology Bispecific antibodies targeting BCMA or GPRC5D are highly effective in relapsed myeloma after CAR T-cell date December 5, 2024 Abstract "Despite the astonishing outcomes after chimeric antigen receptor (CAR) T-cell There are only limited data available on salvage therapies following relapse after BCMA-directed CAR T-cell Here, we analyzed outcomes of post-CAR T-cell therapy relapse and impact of different salvage strategies The median time to relapse after CAR T-cell therapy was 5 months, 53% had the extramedullary disease

The combination of brentuximab vedotin and chidamide synergistically suppresses the proliferation of T-cell through the enhancement of apoptosis Published date November 3, 2023 Abstract " Purpose: Peripheral T-cell HH cells, originating from an aggressive cutaneous T-cell lymphoma, were used as an experimental model Conclusion: The use of chidamide in conjunction with BV may positively affect and enhance T-cellular Junpei Soeda , Yoshihide Kakimoto Tags Apoptosis , Bcl-2 , Brentuximab vedotin , CDC45 , Chidamide , T-cell

Immunology Respiratory infections predominate after day 100 following B-cell maturation antigen-directed CAR T-cell important complication after B-cell maturation antigen (BCMA)-directed chimeric antigen receptor (CAR) T-cell We evaluated infections in 99 adults who received a first BCMA-directed CAR T-cell therapy (commercial and investigational autologous BCMA CAR T-cell products at the recommended phase 2 dose) for relapsed Respiratory infections predominate after BCMA CAR T-cell therapy, particularly after day 100.

< GPCR News < GPCRs in Oncology and Immunology TIPE proteins control directed migration of human T cells two human TIPE family members, TNFAIP8 and TIPE2 were essential for directed migration of human CD4+ T T Cells deficient in both of these proteins completely lost their directionality. Collectively, our work describes a new mechanistic paradigm for how human T cells integrate GPCR and

Alexander Hauser , and Luise Wagner .

Neha Mishra , Thomas Bahmer , Jeanette Franzenburg , Bimba F Hoyer , Andreas Glück , Martina Guggeis , Alexander

this episode Listen to this fantastic round table discussion that I had the privilege to moderate with Alexander

Methods: We disrupted the PR gene (PGR) in ERα-positive/PR-positive T-47D cells using the CRISPR/Cas9 in cell pools we termed PR-low as P4 mediated effects were inhibited or blocked compared to control T- We analyzed the gene expression profiles of PR-low and control T-47D cells in the absence of hormone The overall gene expression pattern was very similar between untreated PR-low and untreated control T- More than 6000 genes were DE in control T-47D cells upon stimulation with P4 or P4 plus E2.

to the positive regulation of macrophage derived foam cell differentiation, negative regulation of T TIMER2.0 and ssGSEA showed that GPR37 expression was significantly associated with the infiltration of T cells, CD8 T cell, eosinophils, macrophages, neutrophils, NK CD56dim cells, NK cells, plasmacytoid DCs (pDCs), T helper cells and T effector memory (Tem) cells.

of 10 kDa (IP-10/CXCL10) is a dual-function CXC chemokine that coordinates chemotaxis of activated T , second messenger signaling downstream of CXCR3, and flow cytometry of CHO cells and primary human T peritoneal ingress of CXCR3+ T lymphocytes in mice. C-terminal residues Lys74-Pro77 of CXCL10 are important for GAG binding, signaling through CXCR3A, T Authors Luna Dillemans , Karen Yu , Alexandra De Zutter , Sam Noppen , Mieke Gouwy , Nele Berghmans ,

of single, combinatorial and complete GRK knockouts in four primary immune cell types (neutrophils, T Combined depletion of GRK2 and GRK6 in T cells and B cells shows distinct functional outcomes for (a) Katharina M Glaser, Teresa K Tarrant, Tim Lämmermann Tags B cells; G-protein coupled receptors; GRK; T

rendered it an attractive target for therapeutic interventions, including monoclonal antibodies, CAR-T cells, and T-cell engagers.

2023 Abstract "Dendritic cells (DCs) and monocytes capture, transport, and present antigen to cognate T Authors Kavita Rawat , Anita Tewari , Xin Li , Arlind B Mara , William T King , Sophie L Gibbings , Chinaza

Here we reported the first comprehensive proteogenomic characterization of natural killer/T-cell lymphoma Therapeutic targeting CCR1 showed promising efficacy with EBV eradication, T-cell activation, and lymphoma

Abstract "The CXCL16-CXCR6 axis is crucial for regulating the persistence of CD8 tissue-resident memory T Chemokine receptors , DRY/DRF/DRL motif , GC-rich gene , GPCR , Mucosal immunology , Tissue-resident memory T

accompanied by decreased creatinine clearance and urea excretion and a decreased presence of regulatory T increased activation of the immune system and a higher production of pro-inflammatory cytokines by T

showed increased CD11b + Gr1+ neutrophils, CD11b + Gr1- monocytes, CD11c+ dendritic cells, and CD4+ T Gpr141 -/- mice increased cytokine production of myelin oligodendrocyte glycoprotein 35-55-specific T

roles of AGPCRs in the periphery ADGRG1/GPR56 regulates survival of terminally differentiated CD8+ T health and disease Douglas Tilley ADGRG1/GPR56 regulates survival of terminally differentiated CD8+ T

McCleskey, sensory neuron properties); Pain Management Research Institute (more opioids, cannabinoids and T-type