deficiency in myeloid cells "Background Eosinophilic inflammation is a hallmark of refractory chronic rhinosinusitis

CRISPR screening reveals that C3aR signaling is critical for rapid capture of fungi by macrophages "The fungal Although it is known that complement components react with the fungal surface, leading to opsonization beads, it is critical for optimal macrophage capture of pathogenic fungi, including Hc, the ubiquitous fungal

Finally, we demonstrated the presence of GLP-1R+CD4+ T cells in skin from patients with allergic contact

volume, airflow obstruction and increased mucus production in asthma; loss of sense of smell in chronic rhinosinusitis , ADCC , AFR , AHR , AR , ASM , Acetylcholine , Airway hyperresponsiveness , Airway smooth muscle , Allergic bronchopulmonary aspergillosis , Allergic fungal rhinosinusitis , Allergic rhinitis , Antibody-dependent gene-related peptide , Chronic idiopathic urticaria , Chronic obstructive pulmonary disease , Chronic rhinosinusitis with nasal polyps , Chronic rhinosinusitis without nasal polyps , Chronic spontaneous urticaria , Colony

I followed my interest in allergy and GPCRs by joining the lab of Dr. RGS4 and RGS5 in airway hyperresponsiveness and lung fibrosis in acute and chronic mouse models of allergic seemingly naïve idea at the dinner table led to a side project by which I characterized the impact of a fungal A fungal serine protease allergen with GPCR-modulating features was discovered as a new biomarker and

Immunology GprC of the nematode-trapping fungus Arthrobotrys flagrans activates mitochondria and reprograms fungal Gene-expression analyses revealed that ascarosides activate the fungal GPCR, GprC, at the plasma membrane functional in A. flagrans, and C. elegans SRBC64/66 and DAF38 share ascaroside-binding sites with the fungal