Oncology and Immunology Metallo-protease Peptidase M84 from Bacillusaltitudinis induces ROS-dependent apoptosis This metallo-protease had no discernible impact on normal cell survival, but it specifically induced apoptosis This evoked apoptotic death of the ovarian cancer cells through the intrinsic route. Collectively, our findings suggested that Peptidase M84 triggered PAR-1-mediated oxidative stress to act as an apoptosis

< GPCR News < GPCRs in Oncology and Immunology CircFKBP5 Suppresses Apoptosis and Inflammation and Promotes Materials and methods: The viability and apoptosis of human DPSCs (hDPSCs) were determined using Cell expression was decreased in hDPSCs and, functionally, reexpression of circFKBP5 attenuated LPS-induced apoptosis Conclusions: CircFKBP5 could protect against LPS-induced apoptosis, inflammation, and osteogenic differentiation

Activation of PI3K/Akt pathway by G protein-coupled receptor 37 promotes resistance to cisplatin-induced apoptosis Furthermore, we examined the effects of GPR37 on tumor cell apoptosis and invasion. that GPR37 positively regulates NSCLC cell invasion, migration, and proliferation, suppresses cell apoptosis observed that GPR37 knockdown suppresses NSCLC cell invasion, migration, and proliferation, promotes cell apoptosis

< GPCR News < GPCRs in Oncology and Immunology Regulator of G protein signaling 16 restrains apoptosis demonstrated that RGS16 promoted the CRC progression, knockdown of RGS16 led to significantly increased apoptosis Mechanistically, RGS16 restrained JNK/P38-mediated apoptosis in CRC cells through disrupting the recruitment

Part II: Cell Cycle, DNA Damage Response, and Apoptosis Pathways Published date October 31, 2023 Abstract Here we describe drug effects on pathways associated with cell cycle, DNA damage response (DDR), and apoptosis Drug combination effects on protein changes in the cell cycle- and apoptosis pathways contribute to the

chidamide synergistically suppresses the proliferation of T-cell lymphoma cells through the enhancement of apoptosis Apoptotic effects of the synergistic partner of BV were further investigated in vitro and in vivo using Further investigations in vitro and in vivo revealed that the levels of an anti-apoptotic protein, Bcl Conclusion: The use of chidamide in conjunction with BV may positively affect and enhance T-cellular apoptotic Tonozuka , Hiroshi Tanaka , Kazumi Nomura , Kazuya Sakaguchi , Junpei Soeda , Yoshihide Kakimoto Tags Apoptosis

Western blotting and flow cytometry were used to evaluate apoptosis and reactive oxygen species (ROS) decreased ROS production as well as proinflammatory factor transcription in macrophages and decreased apoptosis Chen , Jian Zhou , Linlin Wang , Yu Yan , Jun She , Lin Tong , Yuanlin Song Tags Acute lung injury , Apoptosis

Stimulation of GAL2 receptor may modulate immune surveillance and inhibits PDAC via cell cycle inhibition and apoptosis proteins may enhance immune surveillance, prevent carcinogenesis, counter proliferation and stimulate apoptosis

Flowcytometry and Transwell assays were performed to observe the changes in cell apoptosis, metastasis via the signaling pathway of miR-19a/GRK6/GPR39/PKC, which accordingly resulted in suppressed cell apoptosis

processes such as miRNA-mediated gene silencing, positive regulation of ERK cascade, hypoxia-induced apoptosis

Among the five somatostatin receptors, SST2 and SST3 are associated with apoptosis and cell cycle arrest

inhibition indicated that LP2-mediated AT 2 R stimulation inhibited PI3K/AKT/mTOR which resulted in apoptosis

., to adaptively initiate an apoptosis, inflammasome, Nrf2-ARE anti-oxidant, or heat-shock activation

LncRNA) PAXIP1 antisense RNA 1 (PAXIP1-AS1) was found to promote proliferation, migration, EMT, and apoptosis

date July 11, 2023 Abstract "Macrophages release soluble mediators following efferocytic clearance of apoptotic

Inhibition of S1P signaling abrogated the proliferative and anti-apoptotic effects of US28.