Hey there, GPCR Enthusiasts! Are you geared up for your GPCR fix of the day? Get ready to dive into some discoveries and mind-blowing breakthroughs with us! This Week’s Highlights: Congrats to: Our contributor, Cam Sinh Lu ,  who has just released an incredible article on our site and a GPCR Paper with his team: Targeted Drug Design through GPCR Mutagenesis: Insights from β2AR China M Payne ,   Cam Sinh Lu ,   Karen Gregory ,  Lauren May ,  Andrea Vernall , et al. for their fantastic paper on Development of Putative Bivalent Dicovalent Ligands for the Adenosine A1 Receptor Bryan Roth  and Brian Krumm  for their excellent study on Molecular glues as potential GPCR therapeutics Sabrina Rahman , Arthur Christopoulos , Christopher Langmead , et al. for their outstanding work on Ligand-directed biased agonism at human histamine H3 receptor isoforms across Gαi/o- and β-arrestin2-mediated pathways Get ready for the Second class of Principles of Pharmacology I We are diving into the second class of our Principles of Pharmacology I course with enthusiasm and determination! If you missed out on enrolling in this one, worry not – a spot is reserved just for you in Principles of Pharmacology II . Secure your spot now for our next course . Seize this opportunity to enhance your expertise and proficiency in pharmacology! We close registrations in 2 weeks!! Registrants will learn: The powerful applications of new cellular assays to determine GPCR ligand behavior in different functional systems. Understanding real-time kinetics to predict activity and in vivo target coverage. New ligands and new GPCR behaviors that produce unique drug profiles (i.e. intracellular ligands and signaling, location bias, signaling bias). Modules: October 31st : The Eyes to See- The Importance of Pharmacologic Assays. November 7th : Drug Disposition in Physiological Tissues as a Therapeutic Variable. November 14th : The Application of GPCR Ligand Kinetics to Candidate Design. November 21st : Unconventional GPCR Ligands as Drugs. December 5th : Unique Exploitable GPCR-Ligand Behaviors for Therapeutic Benefit. *Lessons are every Thursday at 10 AM EST. 📌 Reasons to Consider Enrolling Now: Cost-effective and Unique Educational Opportunities Our courses offer affordability without compromising on quality. Adaptable Learning Environment Benefit from the flexibility of accessing recorded sessions to deepen your comprehension. Positive Feedback from Our Esteemed Students Past students highly recommend our programs, lauding the course content and the exceptional faculty members who adeptly simplify the intricacies of GPCR pharmacology for practical application in both academic and industrial research settings. Exclusive Deal for Scientists in Developing Nations If you reside and work in a developing country, complete this form for free access to Dr. Kenakin's upcoming course. We aim to make education accessible to all! Take action immediately to join our esteemed learning community! GPCR Event Spotlight 11th Adhesion GPCR Workshop    📍  Mexico City 📅 October 23 - 25, 2024 Hurry, there are only a couple of weeks left! Act now to secure your spot, prepare to spark your passion, and interact with your exceptional peers to explore the latest advancements in adhesion GPCR biology! 🌟 Get ready - the full agenda is now available; check it HERE ! Are you ready to significantly boost your brand? Contact Hello@DrGPCR.com for exciting sponsorship opportunities .  Let's elevate your brand together! Classified GPCR News  Let’s dive into the   Classified GPCR News from September 30th to October 6th, 2024 Industry News Nxera Pharma appoints experienced commercial R&D executive Makoto Sugita as Chief Medical Officer and President of Nxera Pharma Japan Septerna files for IPO on strength of preclinical data, vision for expanding GPCR landscape The Royal Swedish Academy of Sciences has decided to award the Nobel Prize in Chemistry 2024 Septerna Announces Initiation of Phase 1 Clinical Trial with SEP-786, a Novel Oral Small Molecule PTH1R Agonist for the Treatment of Hypoparathyroidism World first: Australian scientists uncover “plant-like” behavior in important human cell regulator, opening up a new drug target for cancer, other diseases Call for GPCR Papers Deadline: Nov 1, 2024. Emerging Voices in GPCR Biology in Special Issue of Molecular Pharmacology GPCR Events, Meetings, and Webinars October 17, 2024 | Unprecedented fragment-based screening using Spectral Shift for GPCRs October 23 - 25, 2024 | 11th Adhesion GPCR Workshop November 5 - 7, 2024 | 16th Annual PEGS Europe   November 25 - 27, 2024 | 1st Virtual GPCR Forum Conference November 26 - 28, 2024 | GPCRs-Targeted Drug Discovery Summit Europe July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology GPCR Jobs HIGHLIGHT Research Associate - Professor Graeme Milligan HIGHLIGHT Postdoc in Molecular Pharmacology - The Hauser Group Postdoctoral Scholar – iPSC in cardiac and endothelial cell function Protein Biochemist/Structural Biologist Senior Scientist/Staff Scientist, Computational Chemistry Postdoc in GPCR mechanosensing   Postdoctoral Position Postdoctoral research position GPCR Activation and Signaling Preassembly of specific Gβγ subunits at GABAB receptors through auxiliary KCTD proteins accelerates channel gating Ligand-directed biased agonism at human histamine H3 receptor isoforms across Gαi/o- and β-arrestin2-mediated pathways Postsynaptic Density Proteins and Their Role in the Trafficking of Group I Metabotropic Glutamate Receptors Dual regulation of IP3 receptors by IP3 and PIP2 controls the transition from local to global Ca2+ signals Coordinated cellular behavior regulated by epinephrine neurotransmitters in the nerveless placozoa Selective ligand recognition and activation of somatostatin receptors SSTR1 and SSTR3 SPMs exert anti-inflammatory and pro-resolving effects through positive allosteric modulation of the prostaglandin EP4 receptor GPCR Binders, Drugs, and more Molecular glues as potential GPCR therapeutics N-acyl glycines produced by commensal bacteria potentiate GLP-1 secretion as GPCR ligands Development of Putative Bivalent Dicovalent Ligands for the Adenosine A1 Receptor GPCRs in Cardiology, Endocrinology, and Taste Ciliary localization of GPR75 promotes fat accumulation in mice GPCRs in Neuroscience Diverse signaling mechanisms and heterogeneity of astrocyte reactivity in Alzheimer's disease Identification of immune-related hub genes in spinal cord injury GPCRs in Oncology and Immunology Biochemical pharmacology of adenylyl cyclases in cancer Olfactory Receptors and Tumorigenesis: Implications for Diagnosis and Targeted Therapy Methods & Updates in GPCR Research Protocol for detecting endogenous GPCR activity in primary cell cultures using ONE-GO biosensors Quantitation of F-actin in cytoskeletal reorganization: Context, methodology and implications Structural and Molecular Insights into GPCR Function LYCHOS is a human hybrid of a plant-like PIN transporter and a GPC R Biochemical characterization of Prokineticin 2 binding to Prokineticin receptor 1 in zebrafish Coupling and Activation of the β1 Adrenergic Receptor - The Role of the Third Intracellular Loop Become a Premium Member! 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August 2022 "The atypical chemokine receptor 1 (ACKR1) was discovered on erythrocytes as the Duffy blood

Immunology Neuroimmune interplay during type 2 inflammation: symptoms, mechanisms and therapeutic targets in atopic and disease and include: skin inflammation, sensitization to pruritogens, and itch amplification in atopic dermatitis and prurigo nodularis; airway inflammation/hyperresponsiveness, loss of expiratory volume aspergillosis , Allergic fungal rhinosinusitis , Allergic rhinitis , Antibody-dependent cellular cytotoxicity , Atopic dermatitis , BAM8-22 , BP , Beta chain , Bovine adrenal medulla peptide 8-22 , Bullous pemphigoid ,

About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Atypical

Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Genetic Deletion of Atypical