Search Results
15 items found for "Autoimmunity"
- Successful prednisolone or calcimimetic treatment of acquired hypocalciuric hypercalcemia caused...
reported as follows: (a) elderly (74-87 years at diagnosis), (b) male, (c) unexpectedly showed no other autoimmune
- β2-Adrenergic Receptor Expression and Intracellular Signaling in B Cells Are Highly Dynamic during..
September 2022 β2-Adrenergic Receptor Expression and Intracellular Signaling in B Cells Are Highly Dynamic during Collagen-Induced Arthritis "The sympathetic nervous system (SNS) has either a pro-inflammatory or anti-inflammatory effect, depending on the stage of arthritis. In the past, treatment of arthritic B cells with a β2-adrenergic receptor (β2-ADR) agonist has been shown to attenuate arthritis. In this study, the expression and signaling of β2-ADR in B cells during collagen-induced arthritis (CIA) were investigated to provide an explanation of why only B cells from arthritic mice are able to improve CIA. Splenic B cells were isolated via magnetic-activated cell sorting (MACS). Adrenergic receptors on B cells and intracellular β2-ADR downstream molecules (G protein-coupled receptor kinase 2 (GRK-2), β-Arrestin 2, p38 MAPK, extracellular signal-regulated kinase 1/2 (ERK1/2) and cAMP response element-binding protein (CREB)) were analyzed at different time points in naïve and arthritic B cells with and without stimulation of β2-ADR agonist terbutaline by flow cytometry. β2-ADR-expressing B cells increase during CIA without a change in receptor density. Moreover, we observed a profound downregulation of GRK-2 shortly after induction of arthritis and an increase in β-Arrestin 2 only at late stage of arthritis. The second messengers studied (p38, ERK1/2 and CREB) followed a biphasic course, characterized by a reduction at onset and an increase in established arthritis. Stimulation of CIA B cells with the β-ADR agonist terbutaline increased pp38 MAPK independent of the timepoint, while pERK1/2 and pCREB were enhanced only in the late phase of arthritis. The phosphorylation of p38 MAPK, ERK1/2 and CREB in the late phase of arthritis was associated with increased IL-10 produced by B10 cells. The change of β2-ADR expression and signaling during sustained inflammation might be an integral part of the switch from pro- to anti-inflammatory action of sympathetic mechanisms in late arthritis." Read more at the source #DrGPCR #GPCR #IndustryNews
- Discovery and In Vivo Evaluation of ACT-660602: A Potent and Selective Antagonist of the Chemokine..
Vivo Evaluation of ACT-660602: A Potent and Selective Antagonist of the Chemokine Receptor CXCR3 for Autoimmune seven-transmembrane G-protein-coupled receptor (GPCR) involved in various pathologies, in particular autoimmune
- Amgen to Acquire Chemocentryx for $4 Billion in Cash
., (NASDAQ: CCXI), a biopharmaceutical company focused on orally administered therapeutics to treat autoimmune
- Developing the Cannabinoid Receptor 2 (CB2) pharmacopoeia: past, present, and future
Promising preclinical data supports the applicability of CB2 activation in autoimmune and inflammatory
- Developing the Cannabinoid Receptor 2 (CB2) pharmacopeia: past, present, and future
Promising preclinical data support the applicability of CB2 activation in autoimmune and inflammatory
- Deficiency of β-arrestin2 alleviates apoptosis through GRP78-ATF6-CHOP signaling pathway in ...
and it participates in inflammatory and immune responses that have been found to mediate apoptosis in autoimmune β-arrestin2 and provided an experimental foundation for β-arrestin2 depletion in the treatment of the human autoimmune
- RAB-Symposium - Regulatory Autoantibodies Targeting GPCRs. September 15-16, 2022. Lübeck, Germany...
autoantibodies targeting GPCRs in various diseases, such as cardiovascular diseases, renal diseases, autoimmune
- A broad look into the future of systemic sclerosis
September 2022 "Systemic sclerosis (SSc) is a systemic autoimmune disease with the key features of inflammation
- 📰 GPCR Weekly News, March 6 to 12, 2023
Binders, Drugs, and more Autoantibodies targeting G protein-coupled receptors: An evolving history in autoimmunity
- Therapeutic validation of an orphan G protein‐coupled receptor
growth, metabolism, and are also linked to major diseases, such as neuroinflammatory, metabolic and autoimmune
- 📰 GPCR Weekly News
in Oncology and Immunology Germinal Center-Related G Protein-Coupled Receptors in Antibody-Mediated Autoimmune
- Chemokine receptor-targeted drug discovery: progress and challenges
The chemokine receptor system is implicated in a wide range of inflammatory, autoimmune and infectious
- 📰 GPCR Weekly News, June 17 to 23, 2024
ROS-dependent apoptosis in ovarian cancer cells by targeting PAR-1 G protein-coupled receptors related to autoimmunity
- 📰 GPCR Weekly News, May 6 to 12, 2024
agonists Discovery of the Clinical Candidate IDOR-1117-2520: A Potent and Selective Antagonist of CCR6 for Autoimmune