studies show that β-arrestin1 drives tauopathy by destabilizing microtubules and impeding p62/SQSTM1 autophagy

for complete autophagy. Inhibition of autophagy by 3-methyladenine or interference of ATG5 or ATG7 attenuated HBx-induced cell The absence of autophagy abolished the phosphorylation of CDK2 and the activity of the CDK2-CCNE1 complex Our results demonstrate that ARRB1 plays a critical role in HBV-related HCC via modulating autophagy related 5; ATG7: autophagy related 7; Baf A1: bafilomycin A1; CDK2: cyclin dependent kinase 2; CDKN1B

taste receptor agonists attenuate macrophage IL‐1β expression and eosinophilic inflammation linked to autophagy Autophagy deficiency in myeloid cells plays a causal role in eosinophilic CRS (ECRS) via macrophage IL ‐1β overproduction, thereby suggesting autophagy regulation as a potential therapeutic modality. Trehalose is a disaccharide sugar with known pro‐autophagy activity and effective in alleviating diverse We sought to investigate the therapeutic potential of autophagy‐enhancing agent, trehalose, or related

GPCRs in Oncology and Immunology High expression of GPR50 promotes the proliferation, migration and autophagy

and Immunology GPR176 Promotes Cancer Progression by Interacting with G Protein GNAS to Restrain Cell Mitophagy GPR176 is confirmed to activate the cAMP/PKA signaling pathway and modulate mitophagy, promoting CRC The GPR176/GNAS complex inhibits mitophagy via the cAMP/PKA/BNIP3L axis, thereby promoting the tumorigenesis Tuo Wang , Peng Yang , Ji'ou Gu , Yifei Feng , Kangpeng Jin , Xiaowei Wang , Yueming Sun Tags GPCR , autophagy