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215 items found for "Bcl-2"

  • Breakfast 2

    Retreat 2023 About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Breakfast 2 Date & Time Saturday, November 4th / 7:30 AM Previous Event Next Event Great Lakes Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec 22nd

  • Ep 101 with Dr Caron Tribute Part 2

    Caron Tribute Part 2 About Marc Caron Dr. Caron was an investigator of the Howard Hughes Medical Institute from 1992 to 2004, a member of the American Jacob Jacobson (2003) Dr. Stephane Laporte (1999) Dr. Stuart Maudsley (1997) Dr.

  • CB2 stimulation of adipose resident ILC2s orchestrates immune balance and ameliorates type 2 diabetes mellitus

    Immunology CB2 stimulation of adipose resident ILC2s orchestrates immune balance and ameliorates type 2 diabetes mellitus Published date July 3, 2024 Abstract "Development of type 2 diabetes mellitus (T2DM ) is associated with low-grade chronic type 2 inflammation and disturbance of glucose homeostasis. Group 2 innate lymphoid cells (ILC2s) play a critical role in maintaining adipose homeostasis via the production of type 2 cytokines.

  • NPFF stimulates human ovarian cancer cell invasion by upregulating MMP-9 via ERK1/2 signaling

    Oncology and Immunology NPFF stimulates human ovarian cancer cell invasion by upregulating MMP-9 via ERK1/2 signaling Published date September 1, 2023 Abstract "Neuropeptide FF (NPFF) belongs to the RFamide peptide Our results also showed that ERK1/2 signaling was activated in SKOV3 cells in response to the NPFF treatment In addition, blocking the activation of ERK1/2 signaling abolished the NPFF-induced MMP-9 expression NPFF stimulates EOC cell invasion by upregulating MMP-9 expression through the NPFFR2-mediated ERK1/2

  • AGPCR 24 Session III

    Authors & Affiliations "Ana Lilia Moreno Salinas (2), Arturo Mancini (1), Raida Jallouli (2), Richard Leduc (2) (1)Domain Therapeutics North America Inc, Montréal, Québec, Canada (2) Department of Pharmacology-Physiology Attendees Authors & Affiliations "Arturo Mancini (2), Samya Aouad (2,3), Herthana Kandasamy (2), Sandra Morrissette (2), Arhamatoulaye Maiga (4), Michel Bouvier (4), Richard Leduc (1), Laurent Sabbagh (2) Department of Pharmacology-Physiology, Université de Sherbrooke, Sherbrooke, Quebec, Canada 2.

  • Spliceosome mutations are associated with clinical response in a phase 1b/2 study of the PLK1 inhibitor onvansertib in combination with decitabine in relapsed or refractory acute myeloid leukemia

    in Oncology and Immunology Spliceosome mutations are associated with clinical response in a phase 1b/2 combination with decitabine in relapsed or refractory acute myeloid leukemia Published date November 1, 2023 In the phase 1b/2 trial, patients with SF mutations (SRSF2, SF3B1) had a higher CR/CRi rate (50%) compared

  • Dr. GPCR Summit 2021 Live Talks

    Albert Kooistra, Gaspar Pandy-Szekeres September 13, 2021 at 2:00:00 PM Learn More >> CXCR4 heteromers Biased β-arrestin 2 Recruitment and Conformation at CXCR3 Dylan S. Jiafei Mao September 14, 2021 at 2:00:00 PM Learn More >> GPCRomics: Identifying novel GPCR targets in Meriem Semache September 15, 2021 at 2:00:00 PM Learn More >> GPCR activation mechanisms across classes Ajay Yekkirala September 16, 2021 at 2:00:00 PM Learn More >> Chaperoning G protein-coupled receptors

  • AGPCR 24 Session I

    L. (1) Arastoo, Mohammad Reza (1) Vejre, Phillip C. (1) Regmi, Rajesh (1) Perry-Hauser, Nicole A. (2) Bendix, Poul Martin (3) Javitch, Jonathan A. (2) Mathiasen, Signe (1) 1. Cechova Kristina3, Bandekar Sumit J.1, 2, Ethan Dintzner1, 2, Leon Katherine1, 2, Dutka Przemysław1, Siffer Gracie3, Kossiakoff Anthony A.1, Sando Richard 4, Vafabakhsh Reza3, Araç Demet1, 2 1. Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago; 2.

  • Ep 29 with Eleonora Comeo

    synthesizing labeled ligands, and her unique position that allows her to work with GPCR scientists on 2

  • GPCR Retreat 2023 | Dr. GPCR Ecosystem

    Retreat 2023 About Program Registration Logo Contest Committee Sponsors 22nd GPCR Retreat Fairmont Le Château Montebello, Québec, Canada November 2-4, 2023 We are pleased to welcome you at Le Château Montebello The meeting will be held on Nov. 2-4, 2023 at the Chateau Montebello, Québec. The deadline for registration is September 21, 2023. Caron keynote lecture on November 2nd. Additionally, there will be a Marc G.

  • AGPCR 24 Student Flash Presentations

    , Abhishek Kumar1; Gunawan, Felix2; Gentile, Alessandra2; Petersen, Sarah C.3; Stainier, Didier Y.R.2; Pathology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Kussmaulallee 12, 91054 Erlangen, Germany 2 Authors & Affiliations "Brodmerkel Lara-Sophie 1, Bormann Anne 1, Seufert Florian 2, Hildebrand Peter We detected and aligned three Adgrf5 exons that undergo differential expression in the kidney: exons 2, Adgrf5 transcripts in FACS-sorted GFP+ ICs do not contain the exon 2 variable region, or the alternative

  • Adhesion GPCR Workshop 2024 Full Agenda

    CINVESTAV, Mexico City, Mexico October 23-25 Full Agenda Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Download PDF Program HERE Oct 23 - 9:00 AM Registration & Welcoming Remarks Adhesion GPCRs As Steroid Hormone Receptors and Hearing and Balance Receptors Jinpeng Sun Read More 2: Leaving for City Center Read More 5:30 PM Mexico City Nocturnal Tour, Food and drinks Read More Oct 24 Mihaylov · Anne Bormann Read More 1:00 PM Lunch Read More 2:00 PM Posters Read More 3:00 PM Session V

  • AGPCR 24 Session II

    Full Agenda Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Download PDF Program of Neurosurgery, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA. 2 of the hypoxia-inducible factor pathway and the epigenetic reader MBD2 (methyl CpG binding protein 2) my PhD thesis, I worked on non-canonical, scaffold driven signaling by protease activated receptor-2 I joined the Department of Biology at Ashoka University in 2020 as an assistant professor."

  • AGPCR 24 Session V

    Full Agenda Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Download PDF Program Institute of Bioanalytical Chemistry, Leipzig University, Deutscher Platz 5, 04103 Leipzig, Germany 2 Langenhan Apr 2016 – Nov 2022 PhD candidate, University Leipzig, Group of Prof. Sträter Oct 2011 – Mar 2016 Master of Science in chemistry, University Leipzig Oct 2008 – Sep 2011 Bachelor Werner1 1 Institute of Medical Physics and Biophysics, Medical Faculty, Leipzig University, Germany 2

  • AGPCR 24 Session IV

    Full Agenda Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Download PDF Program mediated Regulation of Mitochondrial Morphology in Axons Joseph Duman Abstract Only available for AGPCR 24 Mihaylov Abstract Only available for AGPCR 24 Attendees Authors & Affiliations "Flynn, Helen R.2, Sampedro-Castaneda Ligand Interaction In The Adhesion GPCR Latrophilin/Cirl Anne Bormann Abstract Only available for AGPCR 24 to 2020.

  • Ep 87 with Dr. Bianca Plouffe

    mechanisms involved in the angiotensin type 2 receptor (AT2R)-mediated neurite outgrowth while characterizing She identified the structural determinant controlling biased signaling of melatonin type 2 receptors in the context of protection against type 2 diabetes. Seed Award, she investigated biased and compartmentalized G protein signaling by the vasopressin type 2 In 2021, Bianca secured a permanent position as a lecturer.

  • Removing the GPCR-mediated brake on exocytosis enhances insulin action, promotes adipocyte browning, and protects against diet-induced obesity

    Retreat 2023 About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to promotes adipocyte browning, and protects against diet-induced obesity Date & Time Friday, November 3rd / 2: Ceddia 1, *, Zack Zurawski 2,3,*, Analisa Thompson Gray 2, Feyisayo Adegboye 2, Ainsley McDonald-Boyer Hamm 2 1 Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center , Nashville, TN 37232, USA 2 Department of Pharmacology, Vanderbilt University, Nashville, TN 37232,

  • Dr. GPCR Summit 2021 | Dr. GPCR Ecosystem

    GPCR Summit 2021 Welcome to the official page of the Dr. GPCR Virtual Summit 2021! Hurry, the deadline to submit your talk is Friday, September 10th, 2021, at midnight EST. Speakers Step 1: Let us know that you'd like to present your work by filling out this short form here Step 2: How can I sponsor the 2021 Summit? GPCR Summit 2021 Dr. GPCR Summit 2021 Pre-Recorded Talks Dr. GPCR Summit 2021 Live Talks

  • Dr. GPCR Symposia | Dr. GPCR Ecosystem

    Increase the number of events during the calendar year to meet more frequently. 2. Virtual 2. Free for all members 3. Poster presentation 4. Networking GPCRs in Immunology and Oncology November 17, 2023 Details GPCRs as Therapeutic Modalities September 22, 2023 Details Structural and Molecular Insights into GPCR Activation July 21, 2023 Details March 24, 2023 Details SymposiaPrice Premium Monthly $ 24.99 24.99$ Every month Immerse yourself into

  • Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion

    Immunology Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion Published date March 21 , 2023 Abstract " Pancreatic ductal adenocarcinoma (PDAC) continues to show no improvement in survival Invasion assays using a 3D spheroid model revealed P2Y 2 to be critical in facilitating invasion driven mechanistically that this ATP-driven invasion requires direct protein-protein interactions between P2Y 2 DNA-PAINT super-resolution fluorescence microscopy reveals that P2Y 2 regulates the amount and distribution

  • Identification of S1PR4 as an immune modulator for favorable prognosis in HNSCC through machine learning

    immune modulator for favorable prognosis in HNSCC through machine learning Published date September 15, 2023 high-dose cytarabine, granulocyte colony-stimulating factor, and mitoxantrone (CLAG-M) in a phase 1/2 including mitoxantrone 18 mg/m2 per day and sorafenib 400 mg twice daily was declared the recommended phase 2 Four-week mortality was 2%.

  • AGPCR 24 Session VIII

    Full Agenda Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Download PDF Program Neuroanatomy (Würzburg, Germany); 2004-2005: M.Sc . Neuroscience (Oxford, UK); 2005-2009: D.Phil. Neuroscience (Oxford, UK); 2009-2016: Group leader, Institute of Neurophysiology (Würzburg, Germany); 2016: Heisenberg professorship (Würzburg, Germany); 2016-to date: Professor and Chair in Biochemistry Institute for Diabetes and Cancer, Helmholtz Centre Munich, Germany, 2.

  • Orphan receptor GPR50 attenuates inflammation and insulin signaling in 3T3-L1 preadipocytes

    GPR50 attenuates inflammation and insulin signaling in 3T3-L1 preadipocytes Published date November 1, 2022 Abstract Type 2 diabetes (T2DM) is characterized by insulin secretion deficiencies and systemic insulin Jing Long, Long Li, Weicong Qiu, Cairong Li, Jian V Zhang, Pei-Gen Ren Tags Diabetes mellitus type 2;

  • AGPCR 24 Session VII

    Full Agenda Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Download PDF Program modulation of dopaminergic neurotransmission Nicole Perry-Hauser Abstract Only available for AGPCR 24 of Psychiatry and Molecular Pharmacology and Therapeutics, Columbia University, New York, NY 10032; 2Division In 2017, I joined the group of Prof. of Biology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany 2 Rudolf Schönheimer Institute

  • Minireview: functional roles of tissue kallikrein, kinins, and kallikrein-related peptidases in lung cancer

    tissue kallikrein, kinins, and kallikrein-related peptidases in lung cancer Published date July 3, 2023 functions of kinin receptors and KLKs, this review highlights their roles, even considering the SARS-CoV-2 Ehrenfeld Tags KLKs , Kallikrein-related peptidases , Kinin receptors , Kinins , Lung cancer , SARS-CoV-2

  • CircFKBP5 Suppresses Apoptosis and Inflammation and Promotes Osteogenic Differentiation

    Suppresses Apoptosis and Inflammation and Promotes Osteogenic Differentiation Published date May 30, 2023 and alizarin red S staining and detecting the changes of ALP and runt-related transcription factor 2 binding between miR-708-5p and circFKBP5 or G-protein-coupled receptor (GPCR)-kinase interacting protein 2

  • Opposite Effects of Src Family Kinases on YAP and ERK Activation in Pancreatic Cancer Cells: Implications for Targeted Therapy

    Activation in Pancreatic Cancer Cells: Implications for Targeted Therapy Published date November 1, 2022 siRNA-mediated knockdown of YES1, and transfection of epitogue-tagged YAP mutants in PANC-1 and Mia PaCa-2 and synergistically inhibited colony formation by PDAC cells and suppressed the growth of Mia PaCa-2

  • Ep 39 with Dr. Kathryn E Livingston

    There she researched the beta-2 adrenergic receptor and developed assays to investigate real-time activity

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