Authors Xiaoyan Ding , Xiaoxia Li , Yanxia Jiang , Yujun Li , Hong Li , Lipeng Shang , Guilin Feng , Huhu Zhang , Ziyuan Xu , Lina Yang , Bing Li , Robert Chunhua Zhao Tags Autophagy , NSCLC , PKA-Hippo

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< GPCR News < GPCRs in Oncology and Immunology The binding mechanism of an anti-multiple myeloma antibody Furthermore, we elucidate the binding site engaging a sizable extracellular domain on GPRC5D for scFv Authors Pengfei Yan, Xi Lin, Lijie Wu, Lu Xu, Fei Li, Junlin Liu, Fei Xu Source Contribute to the GPCR

Moreover, in silico analysis confirmed a potential binding site of miR-19a on the 3'UTR of GRK6 mRNA, and the subsequent luciferase assays confirmed the molecular binding between GRK6 and miR-19a. Authors Kangjie Shen , Qiangcheng Wang , Lu Wang , Yang Yang , Min Ren , Yanlin Li , Zixu Gao , Shaoluan Zheng , Yiteng Ding , Jiani Ji , Chenlu Wei , Tianyi Zhang , Yu Zhu , Jia Feng , Feng Qin , Yanwen Yang

the downregulated genes (hub genes: IL7r, rt1-bb, rt1-bb1, rt1-da, rt1-ba, cd74, cxcr3, vcam1, ccl5, bin1 Authors Hong Zeng , Li Cheng , De-Zhi Lu , Shuai Fan , Ke-Xin Wang , Li-Li Xu , Bin Cai , Mou-Wang Zhou

greatly limit their clinical applicability. Nanotechnology, as versatile techniques, can encapsulate GPCR ligands to assemble synthetic nano-GPCRs nanoparticles with active targeting capacity for specific cells via ligand-receptor binding and mediate Meanwhile, molecular engineering of nanoparticles with GPCRs or their ligands can modulate membrane binding Authors Yuhong Jiang , Yuke Li , Xiujuan Fu , Yue Wu , Rujing Wang , Mengnan Zhao , Canquan Mao , Sanjun

2,3,*, Analisa Thompson Gray 2, Feyisayo Adegboye 2, Ainsley McDonald-Boyer 3, Fubiao Shi 1, Dianxin Liu 1, Jose Maldonado 5, Jiesi Feng 4, Yulong Li 4, Simon Alford 5, Julio E. The Department’s strengths lie in GPCR signal transduction and neuroscience, and she has expanded it She gave the Fritz Lipmann Lecture at ASBMB in 2001. " Heidi Hamm on the web The Hamm Lab Vanderbilt School of Medicine Pubmed Google Scholar LinkedIn Twitter Dr.

This work focussed on exploring the functions and mechanism of circFKBP5 in DPSC dysfunction evoked by lipopolysaccharide dual-luciferase reporter, RNA immunoprecipitation (RIP), and pull-down assays were used to confirm the binding Authors Cuiwei Liang , Wenmiao Li , Qian Huang , Qitao Wen .

The levels of GPCRRGs were examined in normal and OV cell lines using quantitative reverse-Etranscription Authors Shaohan Ma, Ruyue Li, Guangqi Li, Meng Wei, Bowei Li, Yongmei Li, Chunfang Ha Tags G protein-coupled

<< Live talk schedule >> << Pre-recorded talk list >> The program is complete! Imagine binge-watching your favorite talk over and over whenever you want to during the Summit. In case you'd like to present a talk live, we'll help with it. Email us at Hello@DrGPCR.com << Live talk schedule >> << Pre-recorded talk list >> Meet Dr. GPCR Summit 2021 Live Talks

< GPCR News < GPCRs in Oncology and Immunology The Effect of Cancer-Associated Mutations on Ligand Binding this study, we aimed to investigate the effects of cancer patient-derived 5-HT2C receptor mutations on ligand binding and receptor functionality. This study shows that cancer-associated mutations of 5-HT2C receptor have diverse effects on ligand binding Authors Chenlin Feng, Rongfang Liu, Reno Brooks, Xuesong Wang, Willem Jespers, Marina Gorostiola González

found to promote proliferation, migration, EMT, and apoptosis of ovarian cancer (OC) cells in OC cell lines QRT-PCR was used to validate the expression of PAXIP1-AS1 in OC cell lines. GSEA demonstrated that neutrophil degranulation, signaling by Interleukins, GPCR-ligand binding, G alpha PAXIP1-AS1 was significantly downregulated in OC cell lines compared with IOSE29 cell line. Authors Buze Chen , Xiaoyuan Lu , Qingmei Zhou , Qing Chen , Siyan Zhu , Guilin Li , Hui Liu Source Contribute

GPCR Podcast << Back to podcast list Dr. Qing Fan About this episode Dr. Qing Fan on the web Fan Lab Dr. Fan at Columbia University Research Gate LinkedIn Pubmed Dr. GPCR Ecosystem Thanks for listening to this podcast episode This short survey will help us understand your needs to bring you exciting and informative content; this short survey should take 5 minutes to Listen and subscribe to where you get your podcasts. << Previous Podcast Episode Next Podcast Episode

secretion deficiencies and systemic insulin resistance (IR) in adipose tissue, skeletal muscle, and the liver Furthermore, GPR50 knockout in the 3T3-L1 cell line suppressed PPAR-γ expression. Authors Zhenyu Yao, Jun Meng, Jing Long, Long Li, Weicong Qiu, Cairong Li, Jian V Zhang, Pei-Gen Ren

GPCRs in Oncology and Immunology GPR37 promotes colorectal cancer against ferroptosis by reprogramming lipid that GPR37 protects cancer cells from ferroptosis by upregulating SCD1 expression, thereby modulating lipid Mechanistic studies have shown that GPR37 modulates lipid metabolism in tumor cells by promoting SCD1 Authors Jiamin Zhou, Xigan He, Weixing Dai, Qingguo Li, Zhen Xiang, Yixiu Wang, Ti Zhang, Weiqi Xu, Lu Wang, Anrong Mao Tags Ferroptosis , GPR37 , Lipid metabolism , SCD1 , p38 Source Contribute to the GPCR

Abhishek Kumar Singh Investigating The Role of ADGRB3 Loss of Expression in Brain Tumor Formation in Li-Fraumeni Scholar X (Twitter) Investigating The Role of ADGRB3 Loss of Expression in Brain Tumor Formation in Li-Fraumeni Syndrome Alex Torrelli-Diljohn Abstract "Li-Fraumeni syndrome (LFS) is a rare cancer predisposition Authors & Affiliations "Vukadin L, Park B, Mohamed M, Li H, Elkholy A, Torrelli-Diljohn A, Kim JH, Jeong He is interested in working on Li-Fraumeni syndrome and helping patients afflicted with this condition

< GPCRs in Oncology and Immunology Involvement of Protease-Activated Receptor2 Pleckstrin Homology Binding Previously we identified pleckstrin homology (PH) binding domains within PAR1,2&4 as critical sites for Subsequently, we selected a compound from a library of backbone cyclic peptides generated toward the PAR PH binding motif, namely the lead compound, Pc(4-4). Pc(4-4) binds to the PAR PH binding domain and blocks the association of PH-signal proteins, such as

Authors Jie Xiong , Yu-Ting Dai , Wen-Fang Wang , Hao Zhang , Chao-Fu Wang , Tong Yin , Shu Cheng , Hui-Juan Sheng-Yue Wang , Hai Fang , Rui-Hong Zhang , Yue Zhu , Hong-Mei Yi , Xu-Feng Jiang , Jia-Yi Chen , Li Wang , Peng-Peng Xu , Sai-Juan Chen , Wei-Li Zhao Tags CCR1 , Epstein-Barr virus , Lymphoma , Microenvironment

< Back to Full Agenda Session II AGPCR signaling pathways and trafficking Localization of putative ligands ADGRG6 Drives Proteolytic Processing, Trafficking And Signalling Pal Kasturi Localization of putative ligands Yuling Feng on the web LinkedIn The ADGRF5/GPR116 receptor is a key regulator of lymphatic endothelial His research interest lies in understanding the molecular basis for human tumor development and how to ADGRG6 NTF has multiple extracellular domains like CUB, PTX, SEA, hormone binding domain, and the GAIN

GPCR Podcast << Back to podcast list Dr. Nicolas Gilles About Dr. Nicolas Gilles "Dr. His strongest expertise lies in therapeutic target identification and all the steps from venom manipulations When the pharmacological properties of these new ligands are deemed exceptional, a lead optimization Nicolas Gilles on the web Google Scholar LinkedIn Dr. to bring you exciting and informative content; this short survey should take 5 minutes to fill.

the CMKLR1 N-terminus Published date May 13, 2023 Abstract "The adipokine chemerin is the endogenous ligand of the chemokine-like receptor 1 (CMKLR1), a member of the family of G protein-coupled receptors (GPCR This protein ligand plays an important role in obesity and inflammatory processes. Stable receptor-ligand interactions are highly relevant for its different physiological effects, e. g This may help to develop more potent ligands for the treatment of inflammatory related diseases."

This metabolite binds to and regulates the function of diverse proteins intracellularly to influence oxidative response, epigenetic modification, and gene expression and to signal extracellularly through binding Authors Dan Ye , Pu Wang , Lei-Lei Chen , Kun-Liang Guan , Yue Xiong Tags IRG1/ACOD1 , cancer , inflammatory

Authors Yanni Xi, Zhenya Min, Mianxue Liu, Xueqin Li, Zhao-Hua Yuan Tags P2Y12R , P2Y12R inhibitors ,

GPCR, an ecosystem designed to bring together stakeholders interested in using G-Protein Coupled Receptors GPCR About Ya-Tzu Li Ya-Tzu is a Master's student at the University of South Florida, utilizing large-scale Ya-Tzu Li on the web LinkedIn Dr. Cam Sinh Lu on the web LinkedIn Dr. to bring you exciting and informative content; this short survey should take 5 minutes to fill.

Hence, this study was conducted to identify the interaction sites and binding affinity between several Potential interaction sites and the binding affinity between host and pathogen proteins were identified complexes greatly contribute to the interactions between P. vannamei and V. parahaemolyticus proteins, with binding This finding illustrates the capability of computational approaches to search for molecular binding sites

Oncology and Immunology Natural carboxyterminal truncation of human CXCL10 attenuates glycosaminoglycan binding 73) was compared to intact CXCL10(1-77) using surface plasmon resonance for glycosaminoglycan (GAG) binding Conclusion: Our study shows that the C-terminal residues Lys74-Pro77 of CXCL10 are important for GAG binding Authors Luna Dillemans , Karen Yu , Alexandra De Zutter , Sam Noppen , Mieke Gouwy , Nele Berghmans , Lisa

GPCR Podcast << Back to podcast list Dr. Robert J. His legacy lies in the numerous discoveries he and his team made in the GPCR field and in all those who GPCR Ecosystem Thanks for listening to this podcast episode This short survey will help us understand your needs to bring you exciting and informative content; this short survey should take 5 minutes to Listen and subscribe to where you get your podcasts. << Previous Podcast Episode Next Podcast Episode

GPCR Podcast << Back to podcast list Dr. Roger Sunahara About Dr. Our mission is to understand the mechanism and structural bases for ligand binding and efficacy to help We have identified several GPCR ligands that allosterically modulate orthosteric ligand binding and target Roger Sunahara on the web UCSD Profile Google Scholar ResearchGate LinkedIn Dr. to bring you exciting and informative content; this short survey should take 5 minutes to fill.