September 2022 " Background: Colorectal cancer is the third most common cancer and requires more prognostic biomarkers The expression of several other biomarkers including PPARG, EPCAM, and PD-L1 was investigated by re-analyzing

August 2022 A correlation study of adhesion G protein-coupled receptors as potential therapeutic targets in Uterine Corpus Endometrial cancer "Adhesion G protein-coupled receptors (adhesion GPCRs), as a member of the G protein-coupled receptors (GPCRs) superfamily, have gradually entered the field of vision of researchers. The structure, function, and involvement of adhesion GPCRs in cancer development have been discussed in a series of papers. Uterine Corpus Endometrial Carcinoma (UCEC) isa malignanttumorofendometrium epithelial, whichis alsooneofthemostcommonfemalereproductivesystemtumors, but there are few pieces of research related to adhesion GPCRs in UCEC." Read more at the source #DrGPCR #GPCR #IndustryNews

September 2022 "Research on cancer therapies focuses on processes such as angiogenesis, cell signaling, stemness, metastasis, and drug resistance and inflammation, all of which are influenced by the cellular and molecular microenvironment of the tumor. Different strategies, such as antibodies, small chemicals, hormones, cytokines, and, recently, gene editing techniques, have been tested to reduce the malignancy and generate a harmful microenvironment for the tumor. Few therapeutic agents have shown benefits when administered alone, but a few more have demonstrated clear improvement when administered in combination with other therapeutic molecules. In 2008 (and for the first time in the clinic), the therapeutic benefits of the β-adrenergic receptor antagonist, propranolol, were described in benign tumors, such as infantile hemangioma. Propranolol, initially prescribed for high blood pressure, irregular heart rate, essential tremor, and anxiety, has shown, in the last decade, increasing evidence of its antitumoral properties in more than a dozen different types of cancer. Moreover, the use of propranolol in combination therapies with other drugs has shown synergistic antitumor effects. This review highlights the clinical trials in which propranolol is taking part as adjuvant therapy at single administration or in combinatorial human trials, arising as a good pick and roll partner in anticancer strategies." Read more at the source #DrGPCR #GPCR #IndustryNews

Hepatocellular Carcinoma "Hepatocellular carcinoma (HCC) is at the forefront of the global cancer burden, and biomarkers

through systematic survival analysis on OR genes, OR51E1 (mouse Olfr558) was identified as a potential biomarker of unfavorable overall survival, and OR2C1 (mouse Olfr15) was identified as a potential biomarker of review of the genomic and transcriptomic profiles of ORs in glioma, we suggest that ORs are potential biomarkers

conditions, such as patients with obesity or diabetes, leading to the possibility of using chemerin as a biomarker

The two companies will combine their expertise to identify GPCR targets and associated biomarkers to

and Immunology Expression prevalence and dynamics of GPCR somatostatin receptors 2 and 3 as cancer biomarkers World Congress of Basic and Clinical Pharmacology 2026 GPCR Jobs NEW Principal scientist – oncology biomarker

kinases (SFKs) within PANC-1 cells, as shown by FAK phosphorylation at Tyr576/577 and Tyr861, sensitive biomarkers

Fellow NEW Post-Doc Research Associate NEW Assistant/Associate Professor Principal scientist – oncology biomarker

GPR84 has been additionally proposed to be a potential biomarker in different inflammatory diseases (

cladribine, high-dose cytarabine, G-CSF, and mitoxantrone in untreated AML miR-19a may function as a biomarker

GPCR Activation and Signaling Trans-palmitoleic acid, a dairy fat biomarker, stimulates insulin secretion

Results And Provides Corporate Update Alastair Brown from Sosei Heptares, will present at the 18th Annual Biomarkers

Postdoctoral Fellow Post-Doc Research Associate Assistant/Associate Professor Principal scientist – oncology biomarker

GPCRomics: GPCR Expression in Cancer Cells and Tumors Identifies New, Potential Biomarkers and Therapeutic

CEO Chris Cargill Wins Executive of the Year at the Citeline Pharma Intelligence Awards Japan 2023 BioMap