vasopressin 2 receptor "Abstract Background and purpose: Venomous animals express numerous Kunitz-type peptides The mambaquaretin-1 (MQ1) peptide identified from the Dendroaspis angusticeps venom is the most selective antagonist of the arginine-vasopressin V2 receptor (V2R) and the only unique Kunitz-type peptide active We aimed to exploit other mamba venoms to enlarge the V2R-Kunitz peptide family and gain insight into MQs were produced by solid-phase peptide synthesis and characterized in vitro by binding and functional

several important neurohormonal perturbations, emanating from both the autonomic nervous system and the adrenal The adrenal gland plays an important role in the modulation of cardiac neurohormonal stress because it Synthesis and release of these hormones in the adrenals is tightly regulated by adrenal G protein-coupled In this review, we discuss important aspects of adrenal GPCR signaling and regulation, as they pertain to modulation of cardiac function in the context of chronic HF, by focusing on the 2 best studied adrenal

that removes the inhibitory GAIN domain on the extracellular side of receptor and releases a stalk peptide We further provide physiological evidence of GPR110 activation via stalk peptide.

rhinosinusitis , Allergic rhinitis , Antibody-dependent cellular cytotoxicity , Atopic dermatitis , BAM8-22 , BP , Beta chain , Bovine adrenal medulla peptide 8-22 , Bullous pemphigoid , C-C motif chemokine ligand 17 , CCL17 , CGRP , CIU , COPD , CRSsNP , CRSwNP , CSF2 , CSU , Calcitonin gene-related peptide , Chronic cation channel subfamily M member 4 , Transient receptor potential cation channel subfamily M member 8 Transient receptor potential vanilloid 1 , US Food and Drug Administration , VIP , Vasoactive intestinal peptide

medullary axis and the hypothalamic‒pituitary‒adrenal (HPA) axis. Second, the differential regulation of the gene network between the sympathetic-adrenal medullary axis The level of cortisol, which is mediated by the adrenal glands, was markedly elevated, but norepinephrine The upregulated genes in the adrenal glands (hub genes: Ciart, per2, per3, cry1, and cry2) were enriched Disruption of the connection between the hypothalamus and the adrenal glands causes autonomous regulation

< GPCR News < GPCRs in Oncology and Immunology Chemokine N-terminal-derived peptides differentially regulate Here, we investigate the signaling capacity of peptides corresponding to truncated N-termini. These 3 to 10-residue peptides displayed weak potency but, surprisingly, retained their signaling on In contrast, none of the peptides generated a signal on CCR5, but a CCL3-derived tetrapeptide was a positive